{"id":"W4389229454","doi":"10.1182/blood-2023-187689","title":"Retrospective Study to Evaluate Probability of MR4 Maintenance Following Frontline Nilotinib Dose De-Escalation after MR4 Achievement in the Patients with Chronic Myeloid Leukemia in Chronic Phase","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Nilotinib; Discontinuation; Imatinib; Internal medicine; Imatinib mesylate; Myeloid leukemia; Dasatinib; Tyrosine-kinase inhibitor; Hazard ratio; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008918521,0.0002308467,0.0004122973,0.0008522483,0.0005589222,0.0006626106,0.0003515215,0.000436818,0.0023675],"category_scores_gemma":[0.001750302,0.0002161616,0.0005395293,0.001056814,0.0003588703,0.0006246688,0.0005375133,0.0004497517,0.0005953733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004406888,"about_ca_system_score_gemma":0.0006116693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001191047,"about_ca_topic_score_gemma":0.001129777,"domain_scores_codex":[0.999239,0.0001278977,0.0001517943,0.0002495636,0.0001207474,0.0001111001],"domain_scores_gemma":[0.9980374,0.0002978725,0.000877441,0.0002231821,0.0003024168,0.00026163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002532648,0.00005806183,0.9972159,0.00003239576,0.00002798974,0.0003209451,0.00007230661,0.0000323287,0.0001851024,0.00003661571,0.0001565763,0.001608607],"study_design_scores_gemma":[0.00004385211,0.001214641,0.9909766,0.00002215254,0.0001033503,0.00369169,0.0005506143,0.0002385527,0.0002589818,0.00008776065,0.00279582,0.00001601114],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973032,0.0006298207,0.0002932998,0.00003708631,0.00001181745,0.00007954378,0.0008670766,0.000004130723,0.0007740941],"genre_scores_gemma":[0.9978641,0.0002155916,0.00020506,0.00008152184,0.00003434468,0.00008331964,0.001217198,0.000004044186,0.0002949442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0023675,"threshold_uncertainty_score":0.007920086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0154301107237077,"score_gpt":0.2934922543739572,"score_spread":0.2780621436502494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}