{"id":"W4389229675","doi":"10.1182/blood-2023-180968","title":"XPO2 Is Essential for a Subset of AML Cells and Is a Biomarker for Poor Response and Survival in Pediatric and AYA AML","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto; University Health Network","funders":"","keywords":"Gene knockdown; Biology; RNA interference; Cancer research; Cell culture; Nuclear transport; Importin; Gene expression; Gene; Internal medicine; Medicine; Genetics; RNA; Cell nucleus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003114161,0.0002880182,0.0005634922,0.0009199617,0.000371218,0.0006280542,0.0003347037,0.0003876906,0.006714938],"category_scores_gemma":[0.0007924401,0.0001550609,0.0003787798,0.001312959,0.0001567182,0.0002252427,0.0006425734,0.0003751298,0.002023877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003415812,"about_ca_system_score_gemma":0.0003977279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002793109,"about_ca_topic_score_gemma":0.005076199,"domain_scores_codex":[0.9996494,0.00002213076,0.00003132819,0.0001156988,0.0001375092,0.00004392657],"domain_scores_gemma":[0.999582,0.00008764776,0.000143634,0.00004708218,0.00007077288,0.00006896663],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00395317,0.000157946,0.5932762,0.001779636,0.0005716013,0.001650344,0.0003443271,0.002748809,0.1562404,0.001309549,0.12207,0.1158981],"study_design_scores_gemma":[0.000192167,0.0002243342,0.8416962,0.0001484346,0.000396998,0.003691733,0.000219344,0.002103699,0.02402703,0.001242935,0.1260176,0.00003942896],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6139329,0.004690995,0.002548012,0.0008533132,0.00007955403,0.00007072687,0.3681236,0.001117468,0.008583483],"genre_scores_gemma":[0.5137792,0.002226102,0.002599741,0.0006464467,0.00004628029,0.0001851247,0.4750687,0.0002192393,0.005229112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006714938,"threshold_uncertainty_score":0.02246374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0250054937657704,"score_gpt":0.3125618700007051,"score_spread":0.2875563762349347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}