{"id":"W4389230267","doi":"10.1182/blood-2023-188892","title":"Wilms' Tumor 1 Functions As a Tumor Suppressor to Suppress FLT3-STAT Signaling and Epigenetic Remodeling in Acute Myeloid Leukemia (CALGB 8461, 9665 and 20202; Alliance)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; Terry Fox Research Institute","funders":"","keywords":"Cancer research; Biology; Myeloid leukemia; Epigenetics; NPM1; Oncogene; Transcription factor; Leukemia; Cancer; Immunology; Genetics; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836337,0.000257457,0.0002366418,0.0003943626,0.0001651434,0.0002360118,0.0001480502,0.0001598802,0.00156394],"category_scores_gemma":[0.0001836758,0.0001007121,0.0001583314,0.0003076656,0.0002039828,0.00009943319,0.0002663928,0.0002953742,0.0003649686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004063036,"about_ca_system_score_gemma":0.0002989196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007693395,"about_ca_topic_score_gemma":0.001677933,"domain_scores_codex":[0.9999144,0.000009909295,0.000005275681,0.00002084285,0.00003186918,0.00001772977],"domain_scores_gemma":[0.9999437,0.000006158074,0.00002659153,0.000004515146,0.00000319822,0.00001580189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009289439,0.0002001846,0.03902603,0.0002005383,0.00006325179,0.000702969,0.0001254598,0.001316585,0.8816619,0.001244336,0.003000445,0.07152946],"study_design_scores_gemma":[0.0003608535,0.002298635,0.4817685,0.00003384286,0.0001780626,0.007386295,0.0001308777,0.004896065,0.4474424,0.00112825,0.05435246,0.00002387942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932101,0.002410809,0.001093451,0.0002319546,0.00002226641,0.00004093441,0.0009012951,0.0001457713,0.001943317],"genre_scores_gemma":[0.9940177,0.001351803,0.0008613637,0.0001151377,0.00001474061,0.00004646832,0.001408032,0.00001436033,0.00217032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00156394,"threshold_uncertainty_score":0.005231917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0195803997013537,"score_gpt":0.2866836800774706,"score_spread":0.267103280376117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}