{"id":"W4389230307","doi":"10.1182/blood-2023-184627","title":"Initial Results in a Phase 1b Trial of PB-04 in Sickle Cell Disease Demonstrate Fetal Hemoglobin Induction, Additive Activity with Hydroxyurea, and Improved Red Blood Cell Sickling Parameters","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; University of Toronto; University Health Network","funders":"","keywords":"Fetal hemoglobin; Medicine; Sickle cell anemia; Fetus; Thalassemia; Hemoglobinopathy; Hydroxycarbamide; Internal medicine; Immunology; Disease; Pharmacology; Pregnancy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008811628,0.0009192104,0.001167133,0.00025424,0.0002901063,0.000502291,0.0004209896,0.001210306,0.006763389],"category_scores_gemma":[0.0005281075,0.0001983386,0.0006339297,0.0002375565,0.0005192541,0.0003717919,0.0002510836,0.00252082,0.001109329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003339992,"about_ca_system_score_gemma":0.0004649165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004266441,"about_ca_topic_score_gemma":0.001364178,"domain_scores_codex":[0.9997994,0.00008394563,0.00001272679,0.00003301537,0.00003422964,0.00003671936],"domain_scores_gemma":[0.9997404,0.00006740548,0.00003192827,0.00001544059,0.00002757476,0.0001172109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2222805,0.04467897,0.00565383,0.003555994,0.00185047,0.0009007543,0.0005303393,0.003313676,0.1576957,0.001813203,0.02534324,0.5323834],"study_design_scores_gemma":[0.2978182,0.5870808,0.02424699,0.0002934919,0.0009958845,0.001321981,0.0001206033,0.001643203,0.03149057,0.001207604,0.05371325,0.00006761363],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9388797,0.02275254,0.005262028,0.004274969,0.0004891089,0.006486704,0.006175994,0.0006670608,0.01501205],"genre_scores_gemma":[0.9563848,0.01045818,0.006860292,0.004491672,0.0003325179,0.003738326,0.005300358,0.00009726729,0.01233655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006763389,"threshold_uncertainty_score":0.0226258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241283327770028,"score_gpt":0.2542597314967275,"score_spread":0.2418468982190273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}