{"id":"W4389230397","doi":"10.1182/blood-2023-188513","title":"Assessment of Transduction of CD34+ Human Hematopoietic Stem Cells from Patients with Severe Hemophilia-Α with Lentiviral Vector Carrying a High Expression FVIII Transgene (CD68-ET3-LV)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD34; Genetic enhancement; Stem cell; Haematopoiesis; Viral vector; Transduction (biophysics); Cancer research; Transgene; Biology; Immunology; Medicine; Molecular biology; Cell biology; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184146,0.0001818969,0.0001421204,0.0002710484,0.0001288977,0.000246961,0.00007951779,0.000254089,0.001119811],"category_scores_gemma":[0.0001516436,0.00006940956,0.0001164126,0.0001808539,0.0001525811,0.0001035041,0.0001434493,0.000333403,0.0002117034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009332054,"about_ca_system_score_gemma":0.00006965635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001676967,"about_ca_topic_score_gemma":0.0001492086,"domain_scores_codex":[0.9999068,0.00001964446,0.0000120824,0.00001820399,0.00002864657,0.00001477641],"domain_scores_gemma":[0.9999232,0.00001541214,0.00001846175,0.000006525249,0.00001054786,0.00002583911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001271459,0.0002748102,0.04977125,0.00008417075,0.0000346368,0.001477731,0.0004106459,0.0002209338,0.9303687,0.0001484118,0.0001734344,0.01576385],"study_design_scores_gemma":[0.0003149622,0.01100431,0.4027036,0.00004494943,0.0001950421,0.02343516,0.0005394953,0.003422424,0.5528802,0.0002627786,0.005173789,0.0000232602],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998661,0.0002654905,0.0005865684,0.00001179158,0.000002492813,0.0000245911,0.00005664826,0.00001160183,0.0003797909],"genre_scores_gemma":[0.9988074,0.000176067,0.0005339552,0.00002176345,0.000003288395,0.000019902,0.0002272788,0.000002663986,0.0002077025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119811,"threshold_uncertainty_score":0.003746152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01241849431413095,"score_gpt":0.2566753574163715,"score_spread":0.2442568631022406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}