{"id":"W4389230997","doi":"10.1182/blood-2023-190545","title":"The Presence of Somatic Mutations on Specific Pathways Such As Chromatin Modifier, Spliceosome, and Myeloid Transcription Factor at Diagnosis Was Found to Have Benefit from Allogeneic Hematopoietic Stem Cell Transplantation (HCT) in 1,228 Patients with Acute Myeloid Leukemia in First Complete Remission (CR1)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"","keywords":"Medicine; Transplantation; Oncology; Internal medicine; Somatic evolution in cancer; Hematopoietic stem cell transplantation; Stem cell; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003972767,0.0001788647,0.0002105806,0.0005073228,0.0002426575,0.0003109865,0.0002254067,0.0002424928,0.001089202],"category_scores_gemma":[0.001178436,0.0001326209,0.0001760501,0.0004742744,0.000291591,0.0001849057,0.0001900524,0.0002190582,0.0001668202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004702565,"about_ca_system_score_gemma":0.0003132107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006998929,"about_ca_topic_score_gemma":0.01453992,"domain_scores_codex":[0.999749,0.00004452486,0.00003142335,0.00007573118,0.00005370708,0.00004552049],"domain_scores_gemma":[0.9994227,0.0001597729,0.000251146,0.00005236757,0.00003665659,0.00007732939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001602046,0.00001303051,0.9977251,0.000005096072,0.00001069329,0.00006366528,0.00002131206,0.00004117437,0.0002988772,0.000008270636,0.00004506737,0.001607534],"study_design_scores_gemma":[0.00001320207,0.0001624297,0.9981737,0.000003237288,0.00002666454,0.0006229465,0.00005904819,0.0002151009,0.0003823362,0.00001672824,0.0003226811,0.000001914667],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993019,0.0001087089,0.00005834893,0.0000127895,0.000001934824,0.000006024508,0.0003579668,0.00000189883,0.0001504845],"genre_scores_gemma":[0.9993353,0.00004876942,0.00008084624,0.00001008267,0.000004217095,0.000004935746,0.0003902717,6.70925e-7,0.0001248325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006998929,"threshold_uncertainty_score":0.01391637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02586044753843536,"score_gpt":0.2463739722830469,"score_spread":0.2205135247446116,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}