{"id":"W4389231133","doi":"10.1182/blood-2023-180644","title":"FORTITUDE: A Phase 2 Open-Label Study in Progress to Evaluate Etavopivat for the Treatment of Anemia in Patients with Lower-Risk Myelodysplastic Syndromes","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Anemia; Myelodysplastic syndromes; Medicine; Ineffective erythropoiesis; Internal medicine; Lenalidomide; Population; Erythropoiesis; Gastroenterology; Oncology; Bone marrow; Multiple myeloma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001532275,0.001387311,0.001469217,0.0003493435,0.0003136813,0.001061995,0.001047976,0.001631893,0.0084556],"category_scores_gemma":[0.0006817104,0.0004080986,0.001475674,0.0002787016,0.0007517156,0.001276559,0.00032073,0.00313372,0.001541665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006147561,"about_ca_system_score_gemma":0.001210767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000587309,"about_ca_topic_score_gemma":0.00161064,"domain_scores_codex":[0.9997352,0.00011218,0.00001602627,0.00004641774,0.00003119254,0.00005902032],"domain_scores_gemma":[0.9995722,0.00006361851,0.00009649815,0.00003625143,0.00004496346,0.0001865051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4999676,0.08879817,0.005221096,0.00322239,0.002818585,0.0007361929,0.0004810445,0.004478548,0.08162546,0.001898843,0.02315864,0.2875933],"study_design_scores_gemma":[0.6958928,0.2776311,0.005332949,0.0001658683,0.0004765815,0.000737223,0.00007658222,0.001861008,0.00380351,0.0008045873,0.01317115,0.00004660708],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9501613,0.01624992,0.003983423,0.003657692,0.0007247427,0.009712703,0.006993745,0.0006672734,0.007849343],"genre_scores_gemma":[0.9328576,0.01174171,0.01196373,0.007823284,0.0005356697,0.01203268,0.01070242,0.0001326948,0.01221024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0084556,"threshold_uncertainty_score":0.02828681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0550999316811912,"score_gpt":0.3916374017796931,"score_spread":0.3365374700985019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}