{"id":"W4389231332","doi":"10.1182/blood-2023-184514","title":"Low-Dose Immune Tolerance Induction Therapy for Severe Hemophilia a Inhibitor Patients: Immunosuppressants Improve Outcomes but Are Generally Not Necessary for Inhibitor-Titer below 200 BU/Ml","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Regimen; Rituximab; Prednisone; Internal medicine; Titer; Gastroenterology; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037143,0.0002414852,0.0008093243,0.0002617717,0.0002058505,0.0004399375,0.0002180958,0.0003138671,0.002160493],"category_scores_gemma":[0.0006351232,0.00008050578,0.0005415634,0.0003154053,0.0003247695,0.0004268857,0.0002050595,0.0005327379,0.0002264579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001839897,"about_ca_system_score_gemma":0.0003607566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001199119,"about_ca_topic_score_gemma":0.0002857413,"domain_scores_codex":[0.9997061,0.0001221581,0.00002890656,0.00004514281,0.000038252,0.00005931885],"domain_scores_gemma":[0.9993825,0.0001379501,0.0002256907,0.00004421809,0.0000269935,0.000182615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4782553,0.02858254,0.2490305,0.0008758455,0.001652699,0.0004237363,0.0001412378,0.0008992695,0.03084333,0.000363645,0.001420795,0.2075111],"study_design_scores_gemma":[0.03185927,0.6063498,0.3476913,0.0001253641,0.001384025,0.001142345,0.0001299757,0.001279078,0.007134141,0.00029925,0.002575932,0.00002957971],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979302,0.001312791,0.000111411,0.00003654231,0.00001595516,0.00008920136,0.00008519368,0.000003952114,0.000414655],"genre_scores_gemma":[0.9987692,0.0004152958,0.0001765384,0.00008493703,0.00006270759,0.00008268439,0.0001788568,0.000001459627,0.0002282732],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002160493,"threshold_uncertainty_score":0.00722754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02427120421933908,"score_gpt":0.286608232686677,"score_spread":0.2623370284673379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}