{"id":"W4389231411","doi":"10.1182/blood-2023-182314","title":"Multi-Omic Insights into the Mutational Landscape and Dysregulated Transcriptional Programs of Autoimmune B-Cells in Systemic Lupus Erythematosus","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Spinal Cord Injury BC; University of British Columbia; University Health Network","funders":"","keywords":"Immunology; Biology; Epigenetics; Genetics; B cell; Immune dysregulation; Gene; Immune system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005685943,0.0004049454,0.0006094499,0.001901505,0.0003306123,0.0008660409,0.000376864,0.0004665167,0.002022056],"category_scores_gemma":[0.0004823246,0.0002169057,0.0005618243,0.001143604,0.0002955688,0.0005670157,0.0009274017,0.0008231547,0.0004930024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002881281,"about_ca_system_score_gemma":0.0002411093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004941162,"about_ca_topic_score_gemma":0.001716017,"domain_scores_codex":[0.9997136,0.0000403886,0.00002631036,0.00009020011,0.00009381233,0.00003562909],"domain_scores_gemma":[0.999721,0.00009412085,0.00006835283,0.00003994228,0.00003910769,0.00003737501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006924266,0.00007751885,0.1116516,0.001929926,0.0007360902,0.002968105,0.001213322,0.001894249,0.7073294,0.002473429,0.002969307,0.1660647],"study_design_scores_gemma":[0.00004826743,0.0003362774,0.8171262,0.0009729898,0.001060558,0.01323876,0.001116596,0.006815198,0.06159439,0.01857541,0.07901037,0.0001048148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8703101,0.0746731,0.02664009,0.003104491,0.0001956124,0.00005773491,0.01403189,0.0005868508,0.01040023],"genre_scores_gemma":[0.9369687,0.0261649,0.02285401,0.00204547,0.0002265924,0.00006464395,0.008809127,0.0002078498,0.002658602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002022056,"threshold_uncertainty_score":0.006764472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02101459140265031,"score_gpt":0.2699299704112158,"score_spread":0.2489153790085655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}