{"id":"W4389231608","doi":"10.1182/blood-2023-189165","title":"Ravulizumab Effectiveness in the Real World: Evidence from the International PNH Registry","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Paroxysmal nocturnal hemoglobinuria; Eculizumab; Adverse effect; Real world data; Clinical trial; Intensive care medicine; Internal medicine; Pediatrics; Complement system; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006340811,0.00008858336,0.0001098125,0.00005448924,0.0001086148,0.00003134828,0.0008406588,0.00004016662,0.0003584066],"category_scores_gemma":[0.0003206928,0.00005263026,0.0000581052,0.0002599251,0.00007991161,0.00004980241,0.0001747382,0.0001504685,0.0006324337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000260517,"about_ca_system_score_gemma":0.00004660883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001573413,"about_ca_topic_score_gemma":0.001268688,"domain_scores_codex":[0.998768,0.0006185634,0.0001689491,0.0002099507,0.00006623838,0.0001683161],"domain_scores_gemma":[0.9966738,0.002808654,0.00006623832,0.0004224253,0.00002305527,0.000005808295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001987671,0.0002261224,0.9310164,0.00002143919,0.0002846259,0.00005911332,0.001126842,0.00001095259,0.04063481,0.001116766,0.02453096,0.0007732029],"study_design_scores_gemma":[0.001237142,0.00002145371,0.9853935,0.0002623842,0.00004800747,0.000009041277,0.0005461149,0.000002420908,0.004236675,0.0004813844,0.0076882,0.00007371288],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951537,0.00105379,0.000004486224,0.001358277,0.000687171,0.0003105042,0.00007900432,0.00006575297,0.001287305],"genre_scores_gemma":[0.9989496,0.00006892029,0.000002902478,0.0001002867,0.000100546,0.0001404856,0.0001388887,0.000006501355,0.0004918822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05437706,"threshold_uncertainty_score":0.8128867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03718810960149796,"score_gpt":0.3079690273145952,"score_spread":0.2707809177130973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}