{"id":"W4389231608","doi":"10.1182/blood-2023-189165","title":"Ravulizumab Effectiveness in the Real World: Evidence from the International PNH Registry","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Paroxysmal nocturnal hemoglobinuria; Eculizumab; Adverse effect; Real world data; Clinical trial; Intensive care medicine; Internal medicine; Pediatrics; Complement system; Immunology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01103217,0.000331878,0.001119332,0.001353794,0.0001860014,0.00112216,0.0009596554,0.0004709171,0.002647394],"category_scores_gemma":[0.02954184,0.0002558612,0.001654395,0.003850219,0.0004905926,0.001022993,0.0009724277,0.0007977985,0.0003476758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006618722,"about_ca_system_score_gemma":0.001146656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001974676,"about_ca_topic_score_gemma":0.002763665,"domain_scores_codex":[0.9881828,0.006176236,0.002244367,0.001258591,0.001889069,0.0002489556],"domain_scores_gemma":[0.9527153,0.01824271,0.02382548,0.002489965,0.002097447,0.0006290796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02335906,0.0004550806,0.7089447,0.01945454,0.02239536,0.0003454398,0.0004294589,0.001670713,0.0003874124,0.00168134,0.02393827,0.1969385],"study_design_scores_gemma":[0.007233103,0.002357807,0.9235175,0.007333465,0.0203645,0.001359845,0.0003635895,0.001392644,0.0005370789,0.0009860345,0.03445442,0.00009992805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.707509,0.186987,0.002501046,0.003552178,0.0002937098,0.0009827618,0.08055823,0.000118112,0.01749802],"genre_scores_gemma":[0.9233074,0.04238438,0.002295989,0.001464775,0.0003530135,0.0009994025,0.02881758,0.00003796153,0.0003394001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01103217,"threshold_uncertainty_score":0.05834436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03718810960149796,"score_gpt":0.3079690273145952,"score_spread":0.2707809177130973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}