{"id":"W4389232113","doi":"10.1182/blood-2023-178881","title":"Preclinical and Translational Biomarker Analyses to Inform Clinical Development of Mezigdomide (CC-92480) in Combination with Dexamethasone and Daratumumab in Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre; Dalhousie University","funders":"","keywords":"Daratumumab; Medicine; Bone marrow; Multiple myeloma; Dexamethasone; Cereblon; Biomarker; Peripheral blood mononuclear cell; Antibody-dependent cell-mediated cytotoxicity; Oncology; Internal medicine; Immunology; Bortezomib; Antibody; Monoclonal antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00420003,0.001082523,0.0009498065,0.0006925304,0.000291782,0.001924677,0.0008039066,0.0008198437,0.005166966],"category_scores_gemma":[0.001686247,0.0003659636,0.0006606134,0.0005378856,0.0004873972,0.0008211167,0.0005055303,0.001878077,0.001543074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001584767,"about_ca_system_score_gemma":0.002231225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009858495,"about_ca_topic_score_gemma":0.00299921,"domain_scores_codex":[0.9989977,0.0003425627,0.00006150685,0.000114533,0.0003262897,0.0001573904],"domain_scores_gemma":[0.9990663,0.0001110519,0.0002743459,0.00008082016,0.0002363611,0.0002310422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02079004,0.00768631,0.04174298,0.001397795,0.0007681953,0.0004546199,0.0002055887,0.01048876,0.5632854,0.002174781,0.01624989,0.3347558],"study_design_scores_gemma":[0.0157343,0.2166761,0.1360465,0.0008629375,0.00189372,0.003567707,0.0005278342,0.01891416,0.4201523,0.003641414,0.1817981,0.0001849024],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.877628,0.05602717,0.02039239,0.007082084,0.0005121584,0.004638548,0.008850959,0.001061355,0.02380728],"genre_scores_gemma":[0.9601754,0.008932013,0.01712989,0.00217306,0.0002443616,0.001335162,0.006014938,0.00009203864,0.003903051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005166966,"threshold_uncertainty_score":0.02221215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1846643830559381,"score_gpt":0.4401408400866205,"score_spread":0.2554764570306824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}