{"id":"W4389232150","doi":"10.1182/blood-2023-181541","title":"Optimizing Immunoglobulin Replacement Therapy for Patients with B-Cell Malignancies and Hypogammaglobulinemia: The Investigator-Initiated, International, Randomized Phase II/III Rational Platform Trial, and the Rationalise (STOP IgRT) Domain","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Image-guided radiation therapy; Medicine; Hypogammaglobulinemia; Randomized controlled trial; Internal medicine; Radiation therapy; Oncology; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002368318,0.0002513716,0.000513927,0.00011545,0.0005507133,0.0001436397,0.0002009621,0.00009413168,0.00006873787],"category_scores_gemma":[0.001072212,0.0001270463,0.0001267034,0.0002466073,0.0007938021,0.0001685419,0.0001576346,0.0001894734,0.000004040082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000379068,"about_ca_system_score_gemma":0.002051409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005176907,"about_ca_topic_score_gemma":0.000005077824,"domain_scores_codex":[0.9977674,0.0001640454,0.0005904539,0.0003819753,0.0007789591,0.0003171069],"domain_scores_gemma":[0.9967152,0.002182782,0.0002554826,0.0003508635,0.0003542394,0.0001413764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9822456,0.001545732,0.00007117682,0.00006593845,0.001090481,0.00002184168,0.003167769,0.00005661691,0.0004717745,0.00281002,0.008113758,0.0003392603],"study_design_scores_gemma":[0.9867353,0.001140664,0.00001969797,0.00008844559,0.0002507779,0.00004669116,0.000515711,0.00524013,0.001428771,0.0006449905,0.003731635,0.0001572021],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862561,0.001320086,0.0001852498,0.005276873,0.0001444685,0.006322474,0.00007547781,0.00006269926,0.0003565284],"genre_scores_gemma":[0.9853473,0.003332647,0.003352786,0.001993601,0.0004679936,0.002986421,0.0009231421,0.00006103813,0.001535095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005183513,"threshold_uncertainty_score":0.5180798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778403653257089,"score_gpt":0.2924207048232959,"score_spread":0.264636668290725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}