{"id":"W4389232150","doi":"10.1182/blood-2023-181541","title":"Optimizing Immunoglobulin Replacement Therapy for Patients with B-Cell Malignancies and Hypogammaglobulinemia: The Investigator-Initiated, International, Randomized Phase II/III Rational Platform Trial, and the Rationalise (STOP IgRT) Domain","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Image-guided radiation therapy; Medicine; Hypogammaglobulinemia; Randomized controlled trial; Internal medicine; Radiation therapy; Oncology; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005457331,0.001428791,0.002070801,0.0003567447,0.0004676034,0.002064523,0.0009782881,0.002663721,0.007166465],"category_scores_gemma":[0.005809465,0.0004420908,0.003067977,0.0003773858,0.001508997,0.001248523,0.0006854456,0.003898905,0.0008589399],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001579867,"about_ca_system_score_gemma":0.003252293,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002429706,"about_ca_topic_score_gemma":0.005050544,"domain_scores_codex":[0.9977006,0.001575947,0.0001134643,0.0002342528,0.0001596961,0.0002159788],"domain_scores_gemma":[0.9969618,0.0009917578,0.0009670373,0.0001894576,0.0002749281,0.0006150124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9643866,0.006755032,0.001117422,0.001564338,0.002213341,0.00003022429,0.000097254,0.0005385141,0.0009900229,0.0005044044,0.002427969,0.01937487],"study_design_scores_gemma":[0.957458,0.0369046,0.001366151,0.0002294998,0.0009886381,0.00002206262,0.00003390268,0.0003940738,0.0001948718,0.0004247508,0.001969052,0.00001448379],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9138323,0.01982809,0.002929169,0.00791375,0.002082228,0.0364766,0.00420048,0.0002233245,0.01251409],"genre_scores_gemma":[0.9403262,0.005960404,0.009354261,0.007667552,0.001155145,0.02681831,0.002338147,0.00005913376,0.006320819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007166465,"threshold_uncertainty_score":0.02886146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02778403653257089,"score_gpt":0.2924207048232959,"score_spread":0.264636668290725,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}