{"id":"W4389232433","doi":"10.1182/blood-2023-188285","title":"Targeting Mitochondrial Calcium Uptake to Eradicate Venetoclax-Resistant Acute Myeloid Leukemia Stem Cells","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Ven; Stem cell; Biology; Cancer research; Calcium; Myeloid leukemia; Leukemia; Pharmacology; Cell biology; Immunology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335044,0.0002130518,0.0003182143,0.0002949599,0.0002652386,0.0004658534,0.0002022339,0.0002121026,0.001302945],"category_scores_gemma":[0.0001401947,0.0001049175,0.0001811906,0.0002374869,0.0002130969,0.0001493436,0.0002589643,0.000392437,0.0002817744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003780338,"about_ca_system_score_gemma":0.0002336702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005640319,"about_ca_topic_score_gemma":0.001193404,"domain_scores_codex":[0.9998623,0.00001229909,0.000009425421,0.00004110319,0.00005124808,0.00002355676],"domain_scores_gemma":[0.9999293,0.0000113061,0.0000254167,0.00000799252,0.00001201804,0.00001392613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001323842,0.00002012864,0.00127644,0.0001004436,0.00001041246,0.00005102319,0.00002563961,0.0002149011,0.9932735,0.0001102364,0.0002598077,0.004525097],"study_design_scores_gemma":[0.00006352051,0.0003856929,0.01314731,0.00001956693,0.00003900277,0.0005614341,0.00008707291,0.002276861,0.9684476,0.0001427222,0.01481903,0.00001015285],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890397,0.002628385,0.004993203,0.0001931812,0.00004508056,0.0001074172,0.001223454,0.0002938935,0.001475806],"genre_scores_gemma":[0.9889756,0.001285922,0.005707042,0.0001324179,0.00002081045,0.0001013089,0.001704849,0.00004647301,0.002025482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001302945,"threshold_uncertainty_score":0.004358828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02706268330005987,"score_gpt":0.2896289170301697,"score_spread":0.2625662337301098,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}