{"id":"W4389232625","doi":"10.1182/blood-2023-181765","title":"Efficacy and Safety of Daratumumab (DARA) Monotherapy in Patients with Intermediate-Risk or High-Risk Smoldering Multiple Myeloma (SMM): Final Analysis of the Phase 2 Centaurus Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Internal medicine; Tolerability; Daratumumab; Gastroenterology; Multiple myeloma; Oncology; Lenalidomide; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003251331,0.0007977784,0.001797144,0.0004312875,0.0003627899,0.001843903,0.0006762543,0.0008968825,0.001794562],"category_scores_gemma":[0.001954955,0.0004029004,0.00198177,0.0004510917,0.0006292766,0.0006853823,0.0005321905,0.002139959,0.0006220494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001004289,"about_ca_system_score_gemma":0.0009985256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000551514,"about_ca_topic_score_gemma":0.001743851,"domain_scores_codex":[0.9990987,0.0004830182,0.00005608445,0.0001273477,0.0001136931,0.0001211596],"domain_scores_gemma":[0.9986213,0.0002974073,0.0003414295,0.0001059739,0.0001304375,0.0005033324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6936439,0.009819936,0.0927889,0.002631925,0.00828646,0.0003315858,0.000371797,0.002855085,0.02100745,0.0006985693,0.01289121,0.1546731],"study_design_scores_gemma":[0.3969469,0.3053924,0.2597252,0.0004227821,0.00914101,0.00159473,0.0001991841,0.003900511,0.004518712,0.0009346966,0.01699538,0.0002285514],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814671,0.0130359,0.0001570422,0.0007005263,0.0001349731,0.0003906864,0.0017537,0.00005764147,0.002302473],"genre_scores_gemma":[0.9938189,0.001621084,0.0003478914,0.0008483591,0.0001255485,0.0003246778,0.002397138,0.00001173907,0.0005045587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003251331,"threshold_uncertainty_score":0.01719487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01957714151402078,"score_gpt":0.2954745439370473,"score_spread":0.2758974024230265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}