{"id":"W4389232661","doi":"10.1182/blood-2023-174956","title":"Fixed Duration Mosunetuzumab Plus Polatuzumab Vedotin Has Promising Efficacy and a Manageable Safety Profile in Patients with BTKi Relapsed/Refractory Mantle Cell Lymphoma: Initial Results from a Phase Ib/II Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); McGill University; Jewish General Hospital","funders":"","keywords":"Mantle cell lymphoma; Medicine; Internal medicine; Neutropenia; Ibrutinib; Gastroenterology; Population; Adverse effect; Febrile neutropenia; Oncology; Pharmacology; Lymphoma; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007607337,0.0005739155,0.001039815,0.0002368375,0.0002360588,0.0007478808,0.000453681,0.0003908341,0.001894646],"category_scores_gemma":[0.0004687638,0.0002474307,0.000840034,0.0002963928,0.0004019754,0.0005548142,0.000209398,0.001673128,0.000501416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007810389,"about_ca_system_score_gemma":0.0005711727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007225626,"about_ca_topic_score_gemma":0.002042264,"domain_scores_codex":[0.9997987,0.00006035894,0.00001610544,0.00004096885,0.00003615585,0.00004775058],"domain_scores_gemma":[0.99972,0.00004712853,0.00005448663,0.00002849141,0.00001730232,0.000132528],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2848418,0.04341447,0.02393463,0.001199088,0.002235347,0.0007866899,0.0006068816,0.003714044,0.1600224,0.0002665055,0.00539116,0.473587],"study_design_scores_gemma":[0.1916062,0.6966786,0.08066449,0.0001098333,0.001341467,0.002038555,0.0001753365,0.002546927,0.01527354,0.0002700035,0.009242389,0.00005266383],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944789,0.003073085,0.0004531645,0.0002057295,0.00003134792,0.0003435613,0.0003326679,0.00005283007,0.001028701],"genre_scores_gemma":[0.9962967,0.001308802,0.0006235268,0.0002691923,0.00004855996,0.0002212624,0.000588391,0.00001344678,0.0006301113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001894646,"threshold_uncertainty_score":0.006338239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02544054447726711,"score_gpt":0.2851808303898294,"score_spread":0.2597402859125623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}