{"id":"W4389232661","doi":"10.1182/blood-2023-174956","title":"Fixed Duration Mosunetuzumab Plus Polatuzumab Vedotin Has Promising Efficacy and a Manageable Safety Profile in Patients with BTKi Relapsed/Refractory Mantle Cell Lymphoma: Initial Results from a Phase Ib/II Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); McGill University; Jewish General Hospital","funders":"","keywords":"Mantle cell lymphoma; Medicine; Internal medicine; Neutropenia; Ibrutinib; Gastroenterology; Population; Adverse effect; Febrile neutropenia; Oncology; Pharmacology; Lymphoma; Chemotherapy; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005030488,0.000328768,0.0005461342,0.0004186682,0.000327993,0.0001037458,0.0001592527,0.0001630927,0.0001900884],"category_scores_gemma":[0.0002479544,0.0002900102,0.00005121628,0.0008685093,0.0001079766,0.0002302752,0.0002111822,0.0003775313,0.00005482124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000340127,"about_ca_system_score_gemma":0.0004916585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009850436,"about_ca_topic_score_gemma":0.0002380498,"domain_scores_codex":[0.9968584,0.0002346572,0.0006946918,0.0008239372,0.0008177846,0.0005705881],"domain_scores_gemma":[0.9985117,0.0002787462,0.0002103163,0.000656816,0.0001341905,0.0002082511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4251907,0.1580209,0.08930837,0.001087568,0.002487324,0.00738483,0.0954884,0.0002195259,0.1238446,0.00001211958,0.004099519,0.09285622],"study_design_scores_gemma":[0.5959631,0.01633314,0.3667684,0.0005340085,0.0004598967,0.00001475309,0.001987593,0.002579667,0.01305374,0.00002204643,0.001625429,0.0006582019],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935476,0.0001038829,0.000006585225,0.0001313741,0.00009104954,0.003989358,0.0002131949,0.0001803201,0.001736634],"genre_scores_gemma":[0.9953439,0.00002294724,0.0002573112,0.00002559593,0.0001460066,0.0001098345,0.001313976,0.0000924504,0.002688032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2774601,"threshold_uncertainty_score":0.9999552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02544054447726711,"score_gpt":0.2851808303898294,"score_spread":0.2597402859125623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}