{"id":"W4389232674","doi":"10.1182/blood-2023-181263","title":"Efficacy and Safety of the Anti-Tissue Factor Pathway Inhibitor Marstacimab in Participants with Severe Hemophilia without Inhibitors: Results from the Phase 3 Basis Trial","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Medicine; Factor IX; Clinical endpoint; Adverse effect; Internal medicine; Incidence (geometry); Quality of life (healthcare); Hemostasis; Observational study; Clinical trial; Phases of clinical research; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004013647,0.001101444,0.001745246,0.0001911798,0.0004568658,0.001015844,0.0006824014,0.001461465,0.003801512],"category_scores_gemma":[0.002540135,0.0003057521,0.002145767,0.0003112861,0.0006370398,0.0007337501,0.0004481086,0.002485313,0.0006744167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004617535,"about_ca_system_score_gemma":0.001230119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000517285,"about_ca_topic_score_gemma":0.001194444,"domain_scores_codex":[0.9987379,0.0008558798,0.00006289824,0.0001205804,0.00009227129,0.0001305584],"domain_scores_gemma":[0.9979376,0.0005416612,0.0006324798,0.0001590256,0.0002155954,0.0005137399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9194957,0.007591752,0.009693922,0.00133291,0.002906373,0.0001256301,0.0001785979,0.0004478042,0.005996988,0.000224787,0.005099082,0.04690644],"study_design_scores_gemma":[0.7859563,0.1699889,0.03309987,0.0002065283,0.003116607,0.0004205454,0.0001052554,0.0008264281,0.001376982,0.000630779,0.004223019,0.00004870358],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845473,0.007635029,0.0004155936,0.0009913841,0.0002029904,0.001407538,0.002230186,0.00009271094,0.002477129],"genre_scores_gemma":[0.9903858,0.002460816,0.0008560261,0.001048282,0.0002887803,0.00185119,0.002130326,0.00002009981,0.0009586681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004013647,"threshold_uncertainty_score":0.02122641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04607185591760321,"score_gpt":0.3201263108774575,"score_spread":0.2740544549598543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}