{"id":"W4389233231","doi":"10.1182/blood-2023-181788","title":"The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pediatric Oncology Group","funders":"","keywords":"Lymphoblastic Leukemia; Medicine; Acute lymphocytic leukemia; Drug; Childhood leukemia; Oncology; Leukemia; Pediatrics; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173352,0.0001230524,0.0003226155,0.0002964539,0.0001937483,0.0003680722,0.0001068211,0.0001905915,0.0008472977],"category_scores_gemma":[0.0007861168,0.0001233586,0.0002411748,0.0006769797,0.0001717413,0.0001751759,0.0002205168,0.0002464901,0.0002112286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003343477,"about_ca_system_score_gemma":0.0001517005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002688361,"about_ca_topic_score_gemma":0.004410231,"domain_scores_codex":[0.9996688,0.00005486966,0.00003639389,0.0001077844,0.00006582544,0.00006642478],"domain_scores_gemma":[0.999691,0.00008234329,0.0001361515,0.00002079214,0.00003815437,0.00003164056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003919675,0.00002393194,0.9876903,0.0000353264,0.00005584991,0.0001624453,0.0001867676,0.0001430828,0.003757975,0.0000314248,0.0003958573,0.007125133],"study_design_scores_gemma":[0.000005932883,0.00009958946,0.9965475,0.000006285681,0.00004423362,0.0006205861,0.0002037322,0.0001693169,0.001186635,0.00003619016,0.001075764,0.000004262725],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975246,0.0005857236,0.00008807622,0.00003841957,0.000002497211,0.00000559191,0.001465002,0.00000327368,0.0002869963],"genre_scores_gemma":[0.996933,0.0004664322,0.000252466,0.00009405415,0.00000687182,0.00001443306,0.002072058,0.000005494017,0.0001551247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002688361,"threshold_uncertainty_score":0.005345404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005521756804807384,"score_gpt":0.2412287351149223,"score_spread":0.2357069783101149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}