{"id":"W4389233268","doi":"10.1126/sciadv.adi0508","title":"Genetically engineered transfusable platelets using mRNA lipid nanoparticles","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Creative Research Institute, Hokkaido University; Canadian Blood Services; U.S. Department of Defense","keywords":"Platelet; Messenger RNA; Transfection; Platelet activation; Platelet transfusion; Cell biology; Immunology; Medicine; Chemistry; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000110413,0.0002615327,0.0001385527,0.0001171169,0.00009220713,0.0002513948,0.0001027895,0.0003018314,0.0004866885],"category_scores_gemma":[0.0001243423,0.00009629111,0.0001575555,0.00008242081,0.000189365,0.0001701233,0.0001476373,0.0003859648,0.0002024456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728243,"about_ca_system_score_gemma":0.0001622788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002704774,"about_ca_topic_score_gemma":0.00041229,"domain_scores_codex":[0.9999068,0.00001608781,0.000007681776,0.00002169675,0.00003447684,0.00001333132],"domain_scores_gemma":[0.99994,0.0000155809,0.00002322409,0.000005300391,0.00001028837,0.000005623205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000192764,0.00001206899,0.00004708497,0.00002697485,0.000002504061,0.00005474656,0.00001363644,0.0001052633,0.9972778,0.000269618,0.00004413111,0.002126956],"study_design_scores_gemma":[0.000007458772,0.0001509949,0.0001801603,0.000003328454,0.00001056034,0.0001118587,0.000008301023,0.0005905143,0.9962432,0.00004889649,0.002640884,0.00000373782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9293888,0.001908851,0.06285358,0.0004174359,0.0001568856,0.0001606794,0.0002029909,0.0003302658,0.004580511],"genre_scores_gemma":[0.9577789,0.001818908,0.03446434,0.0001918747,0.00002975323,0.0001108708,0.0002374496,0.00008286829,0.005284937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004866885,"threshold_uncertainty_score":0.00162816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224924113893254,"score_gpt":0.2995567220307804,"score_spread":0.277064310641455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}