{"id":"W4389233268","doi":"10.1126/sciadv.adi0508","title":"Genetically engineered transfusable platelets using mRNA lipid nanoparticles","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Creative Research Institute, Hokkaido University; Canadian Blood Services; U.S. Department of Defense","keywords":"Platelet; Messenger RNA; Transfection; Platelet activation; Platelet transfusion; Cell biology; Immunology; Medicine; Chemistry; Biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001692631,0.0001069659,0.000180483,0.0001547662,0.0002109989,0.00003445186,0.0001212543,0.00002576604,0.00003787906],"category_scores_gemma":[0.00006673094,0.00008394857,0.00003949867,0.001237232,0.0002960108,0.000363319,0.00002172584,0.00005548077,0.0001635502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003717466,"about_ca_system_score_gemma":0.0001374006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001021107,"about_ca_topic_score_gemma":0.000005922739,"domain_scores_codex":[0.9987042,0.000005944789,0.0001440879,0.0003044051,0.0003729672,0.0004683966],"domain_scores_gemma":[0.9995596,0.00002934535,0.00002223558,0.0001686168,0.00005432822,0.0001658975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003788592,0.00008011076,0.002957203,0.00002791759,0.00001372121,0.000268746,0.0001663425,0.002066676,0.9537392,0.00009420368,0.00002468317,0.04052326],"study_design_scores_gemma":[0.00185337,0.0003904561,0.01322764,0.0001081678,0.00006314782,0.0002286468,0.0003557483,0.01393902,0.9619305,0.001202294,0.006415521,0.0002854409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974983,0.0006202866,0.00009521662,0.0003472783,0.0002296298,0.0001725079,0.000004546319,0.0001348378,0.0008973392],"genre_scores_gemma":[0.9959363,0.0002336944,0.003436203,0.00009300149,0.00003810518,0.000008136505,0.000003328013,0.00001027768,0.0002408989],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04023782,"threshold_uncertainty_score":0.3423323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224924113893254,"score_gpt":0.2995567220307804,"score_spread":0.277064310641455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}