{"id":"W4389233276","doi":"10.1182/blood-2023-182099","title":"UM171 Enhances Fitness and Engraftment of Gene Modified Hematopoietic Stem Cells from Sickle Cells Disease Patients","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"","keywords":"Haematopoiesis; Stem cell; Genetic enhancement; Ex vivo; CD34; Cancer research; Biology; Hematopoietic stem cell; Viral vector; Immunology; CD90; Myeloid; Cell biology; In vivo; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001342173,0.0002861469,0.0003543613,0.0002276757,0.0001382257,0.0002939583,0.000133631,0.0001654684,0.00175998],"category_scores_gemma":[0.0001319928,0.00009531715,0.0002666751,0.0001242454,0.0001158446,0.0000967431,0.0002553022,0.0004159674,0.0003798228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009292911,"about_ca_system_score_gemma":0.0001659119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002020905,"about_ca_topic_score_gemma":0.0004185275,"domain_scores_codex":[0.9999108,0.00002299437,0.000009460107,0.00001066579,0.0000195103,0.0000265048],"domain_scores_gemma":[0.9999195,0.00001097936,0.00001665531,0.000005740309,0.000006714585,0.00004038856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001777904,0.0002966311,0.002105128,0.000112072,0.00002681686,0.0002285792,0.000105667,0.0001634048,0.9812682,0.00009354578,0.0002657298,0.01355628],"study_design_scores_gemma":[0.0002106568,0.009259892,0.02573236,0.00003676859,0.0001267258,0.001183989,0.0001479996,0.0008965358,0.9555821,0.0000633401,0.006747926,0.00001181037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983924,0.0007765368,0.000184519,0.00003833027,0.00001191641,0.00001164491,0.0001163854,0.00001917686,0.0004490897],"genre_scores_gemma":[0.9973907,0.0006383847,0.0003734499,0.00006797209,0.00001160221,0.00002191814,0.0005716839,0.00001185212,0.0009124472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00175998,"threshold_uncertainty_score":0.005887687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006413821601569239,"score_gpt":0.2333900717429506,"score_spread":0.2269762501413814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}