{"id":"W4389233282","doi":"10.1182/blood-2023-190037","title":"Trem-Cel, a CRISPR/Cas9 Gene-Edited Allograft Lacking CD33, Shows Rapid Primary Engraftment with CD33-Negative Hematopoiesis in Patients with High-Risk Acute Myeloid Leukemia (AML) and Avoids Hematopoietic Toxicity during Gemtuzumab Ozogamicin (GO) Maintenance Post-Hematopoietic Cell Transplant (HCT)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"","keywords":"CD33; Plerixafor; Myeloid leukemia; CD34; Medicine; Hematopoietic stem cell transplantation; Haematopoiesis; Leukemia; Stem cell; Myeloid; Immunology; Cancer research; Transplantation; Internal medicine; Oncology; Biology; CXCR4; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002275809,0.0002518376,0.0002906396,0.000181788,0.00009575891,0.0002402754,0.000230681,0.0002693494,0.003045995],"category_scores_gemma":[0.0001377798,0.00009017791,0.0002221432,0.000110657,0.0002171153,0.0001227008,0.0001420041,0.0005850123,0.0005138267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002327248,"about_ca_system_score_gemma":0.0002572342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003064642,"about_ca_topic_score_gemma":0.0007257399,"domain_scores_codex":[0.9998871,0.00002019086,0.000007228582,0.00002621961,0.00003516997,0.0000239869],"domain_scores_gemma":[0.9999195,0.00001190203,0.00003004803,0.000008884798,0.000006578423,0.00002310496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004108469,0.001080573,0.00167763,0.0002831033,0.0000819982,0.0003878381,0.00003752061,0.001297674,0.9458914,0.0004288392,0.002128734,0.04259622],"study_design_scores_gemma":[0.002414152,0.01697747,0.01298459,0.00003047081,0.0001751307,0.003852278,0.00003841662,0.00482403,0.9379446,0.0001491647,0.02058175,0.00002791827],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878692,0.0015305,0.004961987,0.0001714732,0.00005188149,0.0001817555,0.001244184,0.0005746618,0.003414256],"genre_scores_gemma":[0.9933562,0.0006002719,0.002803873,0.00007587934,0.000006551275,0.00008727797,0.001360276,0.000032097,0.001677589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003045995,"threshold_uncertainty_score":0.01018989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00656140965244994,"score_gpt":0.2147669923429446,"score_spread":0.2082055826904947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}