{"id":"W4389233329","doi":"10.1182/blood-2023-185956","title":"MRD Directed Treatment Intensification with Either FLAG-Ida or DA-Cladribine Improves Survival in Older AML Patients: Results from the NCRI AML18 Randomised Trial","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Medicine; Cytarabine; Internal medicine; Minimal residual disease; Cladribine; Daunorubicin; Chemotherapy; Gemtuzumab ozogamicin; Chemotherapy regimen; Flag (linear algebra); Randomization; Randomized controlled trial; Oncology; Leukemia; Pediatrics; Surgery; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001896883,0.0008269283,0.001600738,0.0002133144,0.0002028256,0.0006836949,0.0006273462,0.0009127015,0.003979886],"category_scores_gemma":[0.002306525,0.0002475138,0.002171373,0.0002458559,0.0005088178,0.0004805605,0.0004739408,0.002065119,0.0004320391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007510014,"about_ca_system_score_gemma":0.0005184514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401512,"about_ca_topic_score_gemma":0.003153006,"domain_scores_codex":[0.9992549,0.0004522646,0.0000659967,0.00009957311,0.00005421746,0.00007311233],"domain_scores_gemma":[0.9986801,0.0003322675,0.0004386837,0.0001261389,0.00007024011,0.0003525486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.962201,0.001883198,0.003151581,0.0008625084,0.002040587,0.00004806219,0.00006545046,0.000403458,0.00283566,0.0001353204,0.001530032,0.0248431],"study_design_scores_gemma":[0.8979946,0.07021137,0.02105897,0.000273288,0.004582107,0.0001526714,0.00005860695,0.0005731646,0.0006702936,0.0004488217,0.003939836,0.00003621982],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821345,0.01122428,0.0002737546,0.001219544,0.000504589,0.001004666,0.001341214,0.00004521194,0.002252254],"genre_scores_gemma":[0.9870254,0.004309425,0.0009909073,0.001868754,0.0006215833,0.0012461,0.001959981,0.00001488289,0.001962842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003979886,"threshold_uncertainty_score":0.01331407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03474727807158158,"score_gpt":0.2900243781004636,"score_spread":0.255277100028882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}