{"id":"W4389233333","doi":"10.1182/blood-2023-172819","title":"A Phase 3 Study of Eltrombopag Vs. Standard First-Line Management for Newly Diagnosed Immune Thrombocytopenia in Children: Trial in Progress Update","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Eltrombopag; Medicine; Internal medicine; Thrombopoietin receptor; Pediatrics; Thrombopoietin; Randomized controlled trial; Romiplostim; Rituximab; Immune thrombocytopenia; Surgery; Platelet; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002954731,0.001025824,0.002367102,0.0004242134,0.0003781469,0.001738338,0.001014477,0.001828661,0.007283159],"category_scores_gemma":[0.003714505,0.0003615654,0.002659653,0.0006064305,0.0004974505,0.001171112,0.0003956219,0.004707642,0.001073526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009442852,"about_ca_system_score_gemma":0.001959896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072212,"about_ca_topic_score_gemma":0.003537266,"domain_scores_codex":[0.9992249,0.0003942362,0.00006652095,0.00007057347,0.0001447965,0.00009899917],"domain_scores_gemma":[0.9982141,0.000658315,0.0005115895,0.00008800222,0.0001800659,0.0003479447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4566595,0.01039667,0.007857105,0.01166822,0.008334536,0.0006445942,0.0004437571,0.002319605,0.008989681,0.002775289,0.07576699,0.4141441],"study_design_scores_gemma":[0.8403724,0.07976294,0.01312538,0.002235542,0.004249331,0.0009971196,0.0001556628,0.001324625,0.001405978,0.001837404,0.05445944,0.00007422698],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5776842,0.3004331,0.005560341,0.02765672,0.005042402,0.01654421,0.0293429,0.001221828,0.03651431],"genre_scores_gemma":[0.7299966,0.1507473,0.01837318,0.03255827,0.003607765,0.02426863,0.02504564,0.0003658937,0.0150368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007283159,"threshold_uncertainty_score":0.02436459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01794149351890116,"score_gpt":0.3185488502783134,"score_spread":0.3006073567594122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}