{"id":"W4389233388","doi":"10.1182/blood-2023-174955","title":"Janus Kinase (JAK) 1 Inhibition Results in Significant Changes in Serum Proteins and Peripheral T-Cell Populations That Correlated with Clinical Scores in Chronic Graft Versus Host Disease (GVHD) Patients (an Analysis from GRAVITAS-309)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Cohort; Internal medicine; Prednisone; Gastroenterology; Transplantation; Peripheral blood mononuclear cell; Graft-versus-host disease; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001581986,0.0006333194,0.0008225819,0.0003400811,0.0001863188,0.0004238746,0.0002723776,0.0002984802,0.002543095],"category_scores_gemma":[0.0004925719,0.0001813237,0.001272171,0.0004354257,0.0002683928,0.0002267744,0.0003054343,0.001016965,0.0002906556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003510632,"about_ca_system_score_gemma":0.00055675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006170174,"about_ca_topic_score_gemma":0.001640004,"domain_scores_codex":[0.9995728,0.0001516489,0.0000437831,0.00008381663,0.00008861991,0.00005936137],"domain_scores_gemma":[0.9992802,0.0001323007,0.0002317531,0.0000920305,0.00006700453,0.0001968869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4622938,0.007690437,0.2650901,0.001387819,0.006428516,0.0009199607,0.0001712832,0.001447516,0.1329098,0.0001678065,0.01308259,0.1084104],"study_design_scores_gemma":[0.03493915,0.08812226,0.851895,0.00006418168,0.003853396,0.001993229,0.00007130567,0.001471644,0.01045959,0.0001264552,0.006962226,0.0000414492],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937103,0.002258315,0.0001849223,0.0001696525,0.00005156244,0.0001783813,0.002595696,0.00004068951,0.0008105233],"genre_scores_gemma":[0.9939733,0.0006361958,0.0003682827,0.0002382099,0.00006002534,0.00009575443,0.0040323,0.000007167419,0.0005886917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002543095,"threshold_uncertainty_score":0.00850749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04227206653883953,"score_gpt":0.2990799440660886,"score_spread":0.2568078775272491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}