{"id":"W4389233418","doi":"10.1182/blood-2023-182447","title":"Harnessing TCR/CAR Antagonism to Enhance Immunotherapeutic Precision","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"T-cell receptor; Chimeric antigen receptor; Antigen; Adoptive cell transfer; Biology; CD19; Immunology; Immunotherapy; T cell; Cancer research; Leukemia; Cell biology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004093471,0.0005752221,0.0005439605,0.0001911892,0.0001379717,0.0006197586,0.0004590717,0.0006522133,0.0008059393],"category_scores_gemma":[0.0005427638,0.0003232346,0.000393931,0.000164365,0.0003288155,0.0006153443,0.0003940586,0.0008955358,0.0002722636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006614071,"about_ca_system_score_gemma":0.0004415614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005529818,"about_ca_topic_score_gemma":0.0007374813,"domain_scores_codex":[0.999675,0.00004537029,0.00002013275,0.00008275393,0.0001065174,0.00007018621],"domain_scores_gemma":[0.999836,0.00006853962,0.00005461198,0.00001533816,0.0000140741,0.00001147565],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007758712,0.00009629122,0.000597282,0.0001221926,0.00002075053,0.00009435235,0.00003090172,0.1519217,0.8376434,0.00415271,0.000143048,0.005099723],"study_design_scores_gemma":[0.00002346956,0.0003232712,0.0004294627,0.000009500318,0.00002557538,0.0001015158,0.00001445203,0.6596516,0.336615,0.001101956,0.001688883,0.00001524809],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7313253,0.00116029,0.2613904,0.0003030398,0.00004257889,0.0001326801,0.0002412083,0.0004715802,0.004932944],"genre_scores_gemma":[0.9789402,0.0005402007,0.01931473,0.00007989175,0.000007885333,0.00008439239,0.00006292011,0.00002397829,0.0009458858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008059393,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03352593176312137,"score_gpt":0.3582828733063607,"score_spread":0.3247569415432393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}