{"id":"W4389233509","doi":"10.1182/blood-2023-187283","title":"Polyamines Are Required for AML LSC Function through Their Role in Regulating eIF5A Dependent Protein Synthesis","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Biology; Function (biology); Cell biology; Molecular biology; Chemistry; Computational biology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001377117,0.000254274,0.000256036,0.0003525712,0.0002704709,0.0006185106,0.0001307965,0.0002497032,0.001905087],"category_scores_gemma":[0.0002765299,0.0001317256,0.0002807999,0.0002643447,0.0001735061,0.0002707883,0.0003733102,0.0003547536,0.0005182449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003552811,"about_ca_system_score_gemma":0.0002781779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001068775,"about_ca_topic_score_gemma":0.001987809,"domain_scores_codex":[0.9998658,0.00001306521,0.00001520655,0.0000302899,0.00004885277,0.00002673492],"domain_scores_gemma":[0.9998261,0.00001812357,0.00006851241,0.00001439414,0.00003292592,0.00003998535],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003996474,0.00002694743,0.009492563,0.0001067918,0.00001987485,0.0001744305,0.00003991431,0.0001386945,0.9801357,0.0001282614,0.0002229605,0.00911432],"study_design_scores_gemma":[0.00003195398,0.0005160061,0.3163646,0.00005703012,0.00009879996,0.001218219,0.0002641124,0.001731166,0.6616898,0.0002913393,0.01771663,0.00002026438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838721,0.00723257,0.00316863,0.000230349,0.00004485525,0.00004095846,0.002770949,0.0002113151,0.002428236],"genre_scores_gemma":[0.9923706,0.001753063,0.002454903,0.0001123731,0.00001126301,0.00002810611,0.00181669,0.00002951766,0.001423461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905087,"threshold_uncertainty_score":0.006373167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01686368347213393,"score_gpt":0.244173346409192,"score_spread":0.2273096629370581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}