{"id":"W4389233512","doi":"10.1182/blood-2023-177527","title":"Human iPSC-Derived NK Cells with Knock-in of the BCL2 G101V Mutation Are Resistant to Venetoclax and Demonstrate Improved Anti-AML Activity In Vivo","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Venetoclax; Induced pluripotent stem cell; Cancer research; Biology; Immunotherapy; Leukemia; Immunology; Immune system; Embryonic stem cell; Genetics; Gene; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002359764,0.0003067699,0.0003228902,0.0002172246,0.0001650917,0.0004427364,0.0002567826,0.0004467947,0.002512011],"category_scores_gemma":[0.000163336,0.0001546954,0.0002849346,0.0001758899,0.0002729932,0.0002329028,0.000160614,0.001077136,0.0009122624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745788,"about_ca_system_score_gemma":0.0001778155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003526362,"about_ca_topic_score_gemma":0.0005191774,"domain_scores_codex":[0.999723,0.00002532743,0.0000493998,0.0000579492,0.0001077991,0.00003636925],"domain_scores_gemma":[0.9998374,0.00003660921,0.0000428353,0.00003673877,0.00001727678,0.00002909964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009527474,0.00007807664,0.0002292355,0.00004928362,0.00001163602,0.0001147526,0.00002866707,0.0002801426,0.9952462,0.0002627511,0.0002529958,0.003351051],"study_design_scores_gemma":[0.00006196141,0.0002752288,0.002643921,0.00001199183,0.00003978989,0.0007396185,0.00002840409,0.001605469,0.986273,0.000105424,0.008206025,0.000009206966],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9711785,0.001814927,0.01347213,0.0002611353,0.0002129051,0.0001988465,0.00363551,0.0005409421,0.0086851],"genre_scores_gemma":[0.9841623,0.0008224147,0.004571699,0.0001510312,0.00001308389,0.0001493438,0.003585553,0.00007650787,0.006467994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002512011,"threshold_uncertainty_score":0.00840348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02075981551833654,"score_gpt":0.2862143710152169,"score_spread":0.2654545554968804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}