{"id":"W4389233533","doi":"10.1182/blood-2023-173509","title":"Transform-1: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, International Phase 3 Study of Navitoclax in Combination with Ruxolitinib Versus Ruxolitinib Plus Placebo in Patients with Untreated Myelofibrosis","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Medicine; Placebo; Internal medicine; Phases of clinical research; Gastroenterology; Polycythemia vera; Anemia; Clinical trial; Surgery; Oncology; Bone marrow; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002322024,0.001933813,0.002957546,0.0005193073,0.0007048881,0.00132896,0.001260171,0.002023497,0.007846448],"category_scores_gemma":[0.001704099,0.0008589845,0.002096698,0.0004821996,0.001493508,0.001542647,0.0004986426,0.00361553,0.001125577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007900282,"about_ca_system_score_gemma":0.001799432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009934187,"about_ca_topic_score_gemma":0.002340168,"domain_scores_codex":[0.9993929,0.000290542,0.00003796408,0.0001295798,0.00005029822,0.000098761],"domain_scores_gemma":[0.999012,0.0001773964,0.0002701987,0.00006819013,0.00008807063,0.0003840697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9711231,0.01408501,0.0004873952,0.0004097959,0.000554927,0.00003433396,0.00005597246,0.0002195684,0.003496468,0.00009912092,0.0008852764,0.008548983],"study_design_scores_gemma":[0.9376178,0.05989324,0.001122481,0.00002213572,0.0002408269,0.00003191693,0.00001906294,0.0002581806,0.0002853942,0.00008633012,0.0004089794,0.00001358829],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770464,0.004966696,0.001155014,0.001062216,0.0007517499,0.009817444,0.002191531,0.000319236,0.002689755],"genre_scores_gemma":[0.9751968,0.002887856,0.002702466,0.002135779,0.0006816533,0.01102332,0.002232293,0.00005677914,0.003082894],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007846448,"threshold_uncertainty_score":0.02624899,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02273215938856701,"score_gpt":0.3032064606300736,"score_spread":0.2804743012415066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}