{"id":"W4389234269","doi":"10.1182/blood-2023-174501","title":"<i>Cooperative Super-Enhancer Inactivation through Loss of Crebbp and KMT2D Skews B Cell Fate Decisions and Yields T Cell-Depleted Lymphomas</i>","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Spinal Cord Injury BC","funders":"Daiichi Sankyo Europe; Ipsen; DNA Genotek","keywords":"Biology; Enhancer; Chromatin; BCL6; Psychological repression; B cell; Epigenetics; Genetics; Immune system; Germinal center; Cancer research; Transcription factor; Cell biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104397,0.0003787756,0.0002577232,0.0002652877,0.0001315826,0.0003192532,0.0002968549,0.0002426936,0.002277464],"category_scores_gemma":[0.00009806994,0.0001669857,0.0002313557,0.0001369287,0.0003345416,0.0001398454,0.0003257723,0.0006892036,0.0006448258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002340791,"about_ca_system_score_gemma":0.0001677306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007268937,"about_ca_topic_score_gemma":0.00135966,"domain_scores_codex":[0.9997889,0.00002272457,0.00002324901,0.00005693328,0.00005306629,0.00005511247],"domain_scores_gemma":[0.9998426,0.00002354531,0.0000484914,0.00002437503,0.000008154901,0.00005278667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005823234,0.00002433391,0.0001798389,0.00001336461,0.000003270445,0.00003996715,0.000006350477,0.00005171508,0.9988337,0.00006292749,0.00003352211,0.0006928969],"study_design_scores_gemma":[0.00001256469,0.0001694836,0.002384398,0.000002794435,0.00000972403,0.0003536943,0.00001548227,0.0008923221,0.9945318,0.0000217392,0.001602904,0.000003144545],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926143,0.0004895738,0.003725325,0.00009579437,0.00003060169,0.00003788649,0.0006395912,0.0003098107,0.002057129],"genre_scores_gemma":[0.994653,0.0001753639,0.001632492,0.00005443915,0.00001127381,0.00003892777,0.0004733043,0.00008726714,0.002873931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002277464,"threshold_uncertainty_score":0.007618904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01554761858967527,"score_gpt":0.2348396834733903,"score_spread":0.219292064883715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}