{"id":"W4389234334","doi":"10.1182/blood-2023-189351","title":"Novel Therapeutics Targeting Acute Myeloid Leukemia (AML) Stem Cells Identified through High-Throughput Screening","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hôpital de l'Enfant-Jésus; Institute for Research in Immunology and Cancer; McGill University; Université Laval; Université de Montréal; McGill University Health Centre","funders":"","keywords":"Myeloid leukemia; CD34; Leukemia; Stem cell; Haematopoiesis; Cancer research; Cord blood; Medicine; Minimal residual disease; Cytotoxic T cell; Immunology; Acute leukemia; Pharmacology; In vitro; Chemistry; Biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004174194,0.0009577751,0.001205191,0.001207415,0.000309103,0.0005593152,0.000499082,0.0004861706,0.002458584],"category_scores_gemma":[0.0003176532,0.0003155374,0.0007004093,0.0006831536,0.0002285987,0.0003304947,0.0004064841,0.0009140914,0.0007498783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005468464,"about_ca_system_score_gemma":0.0004501806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004863602,"about_ca_topic_score_gemma":0.002381014,"domain_scores_codex":[0.9996562,0.00005729958,0.00002370468,0.00005206117,0.0001557684,0.00005496517],"domain_scores_gemma":[0.9998685,0.0000475515,0.00002080877,0.0000115425,0.00003259178,0.00001902039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003221739,0.0007697685,0.0009036896,0.0006341346,0.00009710275,0.0002194497,0.0000430256,0.003158527,0.9641899,0.0004793464,0.001125919,0.02805701],"study_design_scores_gemma":[0.0002425302,0.005492606,0.004482369,0.00004739686,0.0002827014,0.0005557997,0.00004030364,0.004998299,0.9725308,0.0002536897,0.01103186,0.00004174437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9369779,0.01402397,0.02940627,0.0007133343,0.0001583893,0.002304908,0.005359992,0.001142737,0.009912425],"genre_scores_gemma":[0.9315528,0.01876626,0.03084433,0.0005839069,0.00006898952,0.001625155,0.00618398,0.0001002686,0.01027433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002458584,"threshold_uncertainty_score":0.008224726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04831357275802787,"score_gpt":0.3068427145707464,"score_spread":0.2585291418127185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}