{"id":"W4389234384","doi":"10.1182/blood-2023-181054","title":"Efficacy and Safety Is Maintained in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Pegcetacoplan for up to 3 Years","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Adverse effect; Internal medicine; Hemoglobinuria; Eculizumab; Clinical trial; Incidence (geometry); Anemia; Hemolysis; Surgery; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306021,0.0001314631,0.0002097521,0.0001220697,0.00008635755,0.00001601356,0.0001274368,0.00006670905,0.0001747257],"category_scores_gemma":[0.0001185898,0.0001170861,0.00003182191,0.0001829421,0.00003164508,0.00003631504,0.00008617639,0.00007659556,0.0001147439],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002416096,"about_ca_system_score_gemma":0.00003236495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003380995,"about_ca_topic_score_gemma":0.00009137725,"domain_scores_codex":[0.9990233,0.00006839049,0.0002356247,0.0002845312,0.00004079858,0.0003473097],"domain_scores_gemma":[0.9995066,0.0001639498,0.00006100754,0.0001761538,0.00005255328,0.00003975531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003069966,0.0003738599,0.9738885,0.0001216647,0.0003190961,0.000013885,0.002556395,0.00001365713,0.003613039,0.0001200418,0.01316347,0.002746481],"study_design_scores_gemma":[0.01851276,0.0004058587,0.9756933,0.0001662815,0.00006949796,0.000008588858,0.0003116224,0.000002579624,0.001040053,0.00002520829,0.003570611,0.0001935903],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982001,0.00006134214,0.00001617854,0.0001861108,0.0002378566,0.0008976707,0.0002814209,0.00006428922,0.00005502186],"genre_scores_gemma":[0.9988967,0.000005021933,0.00009402711,0.0001477635,0.00002575302,0.00007734405,0.0002329106,0.00001827723,0.0005022169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01544279,"threshold_uncertainty_score":0.4774634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00843493029343439,"score_gpt":0.2356932878592416,"score_spread":0.2272583575658072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}