{"id":"W4389234384","doi":"10.1182/blood-2023-181054","title":"Efficacy and Safety Is Maintained in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Receiving Pegcetacoplan for up to 3 Years","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Adverse effect; Internal medicine; Hemoglobinuria; Eculizumab; Clinical trial; Incidence (geometry); Anemia; Hemolysis; Surgery; Immunology; Complement system; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001036015,0.0001645924,0.0006001436,0.0001384179,0.0002321255,0.0003479764,0.0001252747,0.0002740564,0.001141288],"category_scores_gemma":[0.001141751,0.00007199436,0.0005335186,0.0002042697,0.0001396851,0.0003445635,0.0001612831,0.000457809,0.0002126281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003250232,"about_ca_system_score_gemma":0.0004074479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004052144,"about_ca_topic_score_gemma":0.001008818,"domain_scores_codex":[0.9997274,0.0000770334,0.00003117677,0.00005291313,0.00004971687,0.00006174797],"domain_scores_gemma":[0.9993148,0.0001248237,0.0002844929,0.0000480565,0.00007039147,0.0001574174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.118932,0.004304778,0.4300081,0.0005172968,0.001294824,0.0006859408,0.0003931206,0.001343342,0.02429477,0.0001566814,0.00405658,0.4140127],"study_design_scores_gemma":[0.007057993,0.09013154,0.8899324,0.00009643903,0.0007784934,0.00172669,0.0001165558,0.001220298,0.002983465,0.0001784905,0.005754836,0.00002276497],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959666,0.001996128,0.0001465789,0.0001356022,0.00001530032,0.00006883466,0.0002923489,0.0000230398,0.001355665],"genre_scores_gemma":[0.9984689,0.0003659562,0.0001900479,0.0001826523,0.00002650325,0.00004540778,0.0004742754,0.000001859217,0.0002443692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001141288,"threshold_uncertainty_score":0.005479038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00843493029343439,"score_gpt":0.2356932878592416,"score_spread":0.2272583575658072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}