{"id":"W4389234406","doi":"10.1182/blood-2023-177591","title":"Molecular Determinants of Response to Mosunetuzumab Plus CHOP in Patients with Previously Untreated (1L) Diffuse Large B Cell Lymphoma (DLBCL)","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"CHOP; Medicine; Rituximab; Oncology; Internal medicine; Lymphoma; Diffuse large B-cell lymphoma; Chemotherapy regimen; Biomarker; Gene signature; Immunology; Chemotherapy; Cancer research; Biology; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002642986,0.000118489,0.0002811095,0.0002728649,0.000154648,0.0003996906,0.0001518531,0.0002557403,0.0009328337],"category_scores_gemma":[0.0006309109,0.0001311612,0.0001747147,0.0003237283,0.0001312231,0.0001787129,0.0001503452,0.0003401881,0.0002100809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000380053,"about_ca_system_score_gemma":0.0001693366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006765028,"about_ca_topic_score_gemma":0.001554256,"domain_scores_codex":[0.9998826,0.00002738332,0.000009221767,0.00003120374,0.00002161193,0.00002808068],"domain_scores_gemma":[0.9996685,0.00009151103,0.0001196937,0.00001056637,0.00002413197,0.00008563085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006396008,0.0002562202,0.9668745,0.00004303391,0.00009223902,0.000225255,0.00008383167,0.0003053836,0.007854375,0.00002611735,0.0004098181,0.01743319],"study_design_scores_gemma":[0.0001561665,0.001648933,0.9955313,0.000007446174,0.00005563924,0.000366652,0.00007436072,0.0009238166,0.0007921013,0.00002863861,0.0004102861,0.000004687187],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994312,0.0002545146,0.00002798039,0.00003534474,0.000002530325,0.000007039669,0.0000904449,0.000002693296,0.0001482191],"genre_scores_gemma":[0.999506,0.00006605271,0.00005591778,0.00003687107,0.000007588796,0.000008772149,0.0002035081,0.000001170308,0.0001140934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009328337,"threshold_uncertainty_score":0.003120661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009579933272469627,"score_gpt":0.2652194575617714,"score_spread":0.2556395242893018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}