{"id":"W4389234564","doi":"10.1182/blood-2023-184921","title":"Management of Hyperleukocytosis in Pediatric Acute Myeloid Leukemia Using Immediate Chemotherapy without Leukapheresis, in Protocol NOPHO-DBH AML-2012","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Cytarabine; Etoposide; Mitoxantrone; Leukapheresis; Internal medicine; Chemotherapy; Chemotherapy regimen; Myeloid leukemia; Leukemia; Gastroenterology; Oncology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001134074,0.0001879196,0.000358433,0.0001974567,0.0002296032,0.000357729,0.0005512367,0.0002887322,0.001784447],"category_scores_gemma":[0.001566934,0.0001027656,0.0002183307,0.0003151718,0.0001836134,0.0002948761,0.0006225301,0.0004950917,0.0002624344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006004579,"about_ca_system_score_gemma":0.001358786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006297448,"about_ca_topic_score_gemma":0.001469661,"domain_scores_codex":[0.9994692,0.0002685424,0.00007026605,0.00006485466,0.00007540618,0.00005162598],"domain_scores_gemma":[0.9994443,0.0001068371,0.0002226267,0.00004146389,0.00004563386,0.0001390555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.05388375,0.005671436,0.4285567,0.004212743,0.0004420072,0.00179659,0.0009394176,0.004396029,0.03134555,0.001542208,0.01693632,0.4502773],"study_design_scores_gemma":[0.0209968,0.05811577,0.7962286,0.001206189,0.0005969211,0.006576028,0.0005060984,0.001925749,0.01894438,0.0007891126,0.09405719,0.0000572086],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817783,0.005100327,0.001735275,0.0007153341,0.00006090315,0.003085265,0.001558474,0.00004661118,0.005919649],"genre_scores_gemma":[0.9785466,0.003036078,0.00634115,0.0009354338,0.0001220475,0.004773341,0.005100941,0.00001917709,0.001125281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001784447,"threshold_uncertainty_score":0.005997598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02525566120483506,"score_gpt":0.3217265118947948,"score_spread":0.2964708506899598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}