{"id":"W4389234575","doi":"10.1182/blood-2023-173550","title":"Longitudinal Correlative Profiles of Responders, Nonresponders, and Those with Relapse on Treatment with Teclistamab in the Phase 1/2 MajesTEC-1 Study of Patients with Relapsed/Refractory Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Bone marrow; Internal medicine; CD8; Cytopenia; Oncology; Immune system; Gastroenterology; Multiple myeloma; Flow cytometry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009493894,0.0002108672,0.000400812,0.0003869883,0.00034009,0.0004731739,0.0002162179,0.00038265,0.001025334],"category_scores_gemma":[0.000983448,0.0001703322,0.000365253,0.0002748244,0.0001657879,0.0003612784,0.0002719852,0.0005792425,0.0002469462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116484,"about_ca_system_score_gemma":0.0002521999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007835194,"about_ca_topic_score_gemma":0.001139088,"domain_scores_codex":[0.999543,0.0001311815,0.00004270051,0.0001353337,0.00007273485,0.00007521144],"domain_scores_gemma":[0.999204,0.0001095279,0.0002848302,0.00006862693,0.0000829945,0.0002500869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.009869631,0.0005943618,0.9771851,0.00002285275,0.0001787636,0.00009115421,0.0001123694,0.0001702248,0.004033186,0.000016828,0.0003372106,0.007388295],"study_design_scores_gemma":[0.0003740722,0.004644703,0.9931809,0.000006291496,0.0001085126,0.0002517999,0.00008728504,0.0003708731,0.0004571747,0.00002230695,0.0004871392,0.000009122959],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992757,0.0001776054,0.0000305658,0.00002173271,0.000003770841,0.00002020428,0.0002190668,0.000004646458,0.0002466369],"genre_scores_gemma":[0.9990358,0.00003946342,0.00005031949,0.00004470666,0.000009774069,0.00002671156,0.0005776562,0.000001878682,0.0002136665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001025334,"threshold_uncertainty_score":0.005020857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04014223672840837,"score_gpt":0.3146885644147789,"score_spread":0.2745463276863706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}