{"id":"W4389234838","doi":"10.1182/blood-2023-178546","title":"Long-Term Evaluation of Luspatercept in Erythropoiesis-Stimulating Agent (ESA)-Intolerant/Refractory Patients (pts) with Lower-Risk Myelodysplastic Syndromes (LR-MDS) in the Phase 3 MEDALIST Study","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Cumulative incidence; Myelodysplastic syndromes; Internal medicine; Adverse effect; Anemia; International Prognostic Scoring System; Refractory (planetary science); Phases of clinical research; Clinical trial; Surgery; Gastroenterology; Cohort; Bone marrow","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001821971,0.0006657007,0.00105169,0.0002072053,0.0003327346,0.000761991,0.0004705888,0.0006271845,0.001824511],"category_scores_gemma":[0.0007913407,0.0002617952,0.00120476,0.0002426912,0.000373018,0.0005809587,0.0002843935,0.001757625,0.0006084649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005471352,"about_ca_system_score_gemma":0.0006571712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002724488,"about_ca_topic_score_gemma":0.000827788,"domain_scores_codex":[0.9996619,0.0001575814,0.00003008094,0.00005428384,0.00004430678,0.00005188819],"domain_scores_gemma":[0.9991648,0.0001059683,0.0002882083,0.00005949693,0.0000578137,0.0003237105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7495121,0.03436394,0.03984626,0.001345154,0.003834757,0.0004411455,0.000415902,0.003630391,0.03610214,0.0003054,0.004656853,0.1255461],"study_design_scores_gemma":[0.2371971,0.6549934,0.09219907,0.00009547817,0.002468974,0.0007316647,0.00009655555,0.002592833,0.004708386,0.0003104298,0.004551956,0.00005412011],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995325,0.002268267,0.0002313462,0.0001892628,0.00004402823,0.000397233,0.0005837203,0.00003207105,0.0009291281],"genre_scores_gemma":[0.9965008,0.0006703872,0.0003229235,0.0002982911,0.000075262,0.0004311672,0.0009548564,0.000007206534,0.0007390132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001824511,"threshold_uncertainty_score":0.009635568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04973880724398392,"score_gpt":0.3599468793225341,"score_spread":0.3102080720785502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}