{"id":"W4389234885","doi":"10.1182/blood-2023-180114","title":"Nivolumab-AVD Is Better Tolerated and Improves Progression-Free Survival Compared to Bv-AVD in Older Patients (Aged ≥60 Years) with Advanced Stage Hodgkin Lymphoma Enrolled on SWOG S1826","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Neutropenia; Progression-free survival; Regimen; Chemotherapy regimen; Phases of clinical research; Surrogate endpoint; Oncology; Surgery; Clinical trial; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007556997,0.00028301,0.0008772451,0.0001650044,0.0001422771,0.0003742695,0.0002174463,0.0002542388,0.001552586],"category_scores_gemma":[0.0007386731,0.0001390239,0.0006729958,0.0001756638,0.0001859608,0.0003486415,0.0001802236,0.0005417423,0.0002073583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000319897,"about_ca_system_score_gemma":0.0003109928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004653904,"about_ca_topic_score_gemma":0.001664254,"domain_scores_codex":[0.9998223,0.00007092533,0.00001697723,0.00003263945,0.00002215825,0.00003499729],"domain_scores_gemma":[0.9996519,0.00006762762,0.0001004496,0.00001937104,0.0000186272,0.0001420366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6496727,0.01115488,0.107821,0.0009049291,0.002163428,0.0001775921,0.0002289569,0.001916507,0.02100427,0.00009917469,0.003661871,0.2011947],"study_design_scores_gemma":[0.1336258,0.4156703,0.4334451,0.0001915083,0.002016758,0.0006514117,0.0001886196,0.003283296,0.003944765,0.0003112281,0.006623846,0.0000473428],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998041,0.001190494,0.00005015546,0.00007016638,0.00003189717,0.00005450952,0.000165871,0.00001191946,0.0003840027],"genre_scores_gemma":[0.9985399,0.0004741587,0.0001088856,0.0001562945,0.00004237008,0.00004883882,0.0002833117,0.000002827128,0.0003434516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001552586,"threshold_uncertainty_score":0.005193889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009811042039027357,"score_gpt":0.2577601420561951,"score_spread":0.2479491000171678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}