{"id":"W4389234887","doi":"10.1182/blood-2023-174550","title":"Trial in Progress: A Phase 1 Study of KTX-1001, an Oral, First-in-Class, Selective MMSET Inhibitor in Patients with Relapsed and Refractory Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Multiple myeloma; Internal medicine; Oncology; Population; Pharmacodynamics; Pharmacokinetics; Cmax; Adverse effect; Pharmacology; Phases of clinical research; Refractory (planetary science); Clinical trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001670926,0.0001297465,0.0001984594,0.0001775514,0.00002258208,0.000008528153,0.0000639112,0.0001456057,0.000001313086],"category_scores_gemma":[0.00007100222,0.0001238915,0.00001671182,0.000454387,0.00004316937,0.00001187482,0.00004579237,0.0001066949,4.678826e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003170059,"about_ca_system_score_gemma":0.00008262536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001310119,"about_ca_topic_score_gemma":0.007939075,"domain_scores_codex":[0.9988955,0.0001147017,0.0002829288,0.0003738492,0.000148967,0.0001840713],"domain_scores_gemma":[0.9995632,0.00001656503,0.000117263,0.000204536,0.00005852911,0.0000399406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03289247,0.01265551,0.9348696,0.00003197532,0.00009280747,0.00001547601,0.001434487,0.0002129777,0.01401492,3.454379e-7,0.0001188422,0.003660533],"study_design_scores_gemma":[0.2440781,0.01501759,0.7220253,0.00006617933,0.0000360032,7.501935e-7,0.0003396547,0.0002459546,0.0178182,0.000004103334,0.0001561579,0.0002119251],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984102,0.0001005208,3.604194e-7,0.00001483337,0.00005124528,0.001381531,0.00002424938,0.00001111467,0.000006006713],"genre_scores_gemma":[0.9995017,0.00001620775,0.0000396627,0.000003221548,0.00005165484,0.0001444427,0.0002119033,0.00002184113,0.000009349169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2128443,"threshold_uncertainty_score":0.5052148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008988037532944677,"score_gpt":0.2598973326990254,"score_spread":0.2509092951660807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}