{"id":"W4389234887","doi":"10.1182/blood-2023-174550","title":"Trial in Progress: A Phase 1 Study of KTX-1001, an Oral, First-in-Class, Selective MMSET Inhibitor in Patients with Relapsed and Refractory Multiple Myeloma","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Tolerability; Medicine; Multiple myeloma; Internal medicine; Oncology; Population; Pharmacodynamics; Pharmacokinetics; Cmax; Adverse effect; Pharmacology; Phases of clinical research; Refractory (planetary science); Clinical trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001949592,0.002252126,0.002601563,0.0005099006,0.0006402899,0.001788188,0.001409627,0.002418841,0.008085722],"category_scores_gemma":[0.001234362,0.000695657,0.001509123,0.000632553,0.001131582,0.001567772,0.000534337,0.005573811,0.001910066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001041606,"about_ca_system_score_gemma":0.002183082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009951741,"about_ca_topic_score_gemma":0.002906987,"domain_scores_codex":[0.999529,0.0002012276,0.0000212225,0.0000957279,0.0000510412,0.0001018672],"domain_scores_gemma":[0.9990213,0.0001353637,0.0001979949,0.00007871947,0.0000765681,0.0004899412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7363589,0.07519309,0.006591833,0.00252011,0.002746622,0.0006538299,0.0005214029,0.003440523,0.04484927,0.0006505047,0.01527337,0.1112005],"study_design_scores_gemma":[0.7365046,0.2468405,0.007091986,0.00007849812,0.0004990061,0.0005366768,0.00009161603,0.001229921,0.002227097,0.0004093463,0.004449394,0.00004124526],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9670373,0.007092323,0.001506904,0.002441352,0.0004427775,0.007607826,0.007097894,0.0005257311,0.006247938],"genre_scores_gemma":[0.9536305,0.006948887,0.003817846,0.00438662,0.0003984111,0.009290327,0.01145413,0.0001350694,0.009938199],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.008085722,"threshold_uncertainty_score":0.02704948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008988037532944677,"score_gpt":0.2598973326990254,"score_spread":0.2509092951660807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}