{"id":"W4389235362","doi":"10.1182/blood-2023-178819","title":"Extended Follow-up and Resistance Mutations in CLL Patients Treated with Acalabrutinib","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Bruton's tyrosine kinase; Ibrutinib; Chronic lymphocytic leukemia; Medicine; Progressive disease; Peripheral blood mononuclear cell; Somatic evolution in cancer; Immunology; Internal medicine; Cancer research; Oncology; Leukemia; Tyrosine kinase; Cancer; Chemotherapy; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004406741,0.0002295785,0.0004589247,0.001097173,0.0008454597,0.0007528544,0.0003514188,0.000752984,0.001947652],"category_scores_gemma":[0.001294646,0.0001651128,0.0003887326,0.001039561,0.0002083216,0.0007119577,0.000515527,0.0009619156,0.0003634263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008737335,"about_ca_system_score_gemma":0.0004118713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00401566,"about_ca_topic_score_gemma":0.003690785,"domain_scores_codex":[0.9995673,0.00006639086,0.00004082958,0.0001103684,0.00008658935,0.0001284219],"domain_scores_gemma":[0.9990829,0.0001223045,0.000316263,0.00005177096,0.0001319433,0.0002948458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001170903,0.0001144764,0.9871644,0.00001774184,0.00003085253,0.001396886,0.0002028222,0.00007870907,0.001033674,0.00002550535,0.0003616352,0.008402362],"study_design_scores_gemma":[0.00005442161,0.0005749095,0.9936982,0.00002977761,0.00008893132,0.003200316,0.000215433,0.000276381,0.0002347627,0.00009725267,0.001515077,0.00001436558],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970446,0.00094362,0.00006625451,0.0001559258,0.00001074661,0.00001972414,0.0004856265,0.00001216929,0.001261398],"genre_scores_gemma":[0.998866,0.0001798962,0.00005357563,0.0001186602,0.00002265125,0.00002065389,0.0005180528,0.000002499598,0.0002180606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00401566,"threshold_uncertainty_score":0.007984579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767307885723865,"score_gpt":0.2852902259037935,"score_spread":0.2676171470465548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}