{"id":"W4389235362","doi":"10.1182/blood-2023-178819","title":"Extended Follow-up and Resistance Mutations in CLL Patients Treated with Acalabrutinib","year":2023,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"AstraZeneca (Canada)","funders":"","keywords":"Bruton's tyrosine kinase; Ibrutinib; Chronic lymphocytic leukemia; Medicine; Progressive disease; Peripheral blood mononuclear cell; Somatic evolution in cancer; Immunology; Internal medicine; Cancer research; Oncology; Leukemia; Tyrosine kinase; Cancer; Chemotherapy; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266667,0.0001019817,0.0001854998,0.0001730739,0.00004907851,0.0000144131,0.00005488393,0.00005411758,0.00002407514],"category_scores_gemma":[0.0002408224,0.00008007513,0.00002154275,0.0007803626,0.00008804209,0.00004905841,0.00003915843,0.0001229724,0.00005601684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006269285,"about_ca_system_score_gemma":0.0008931886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001519763,"about_ca_topic_score_gemma":0.0004104817,"domain_scores_codex":[0.9988897,0.00003522028,0.000170355,0.0002693825,0.0003263657,0.0003089701],"domain_scores_gemma":[0.9993974,0.0001264966,0.00003088317,0.000235558,0.00008909957,0.000120561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005383767,0.004658415,0.9582946,0.001240602,0.0007376325,0.006116305,0.004847806,0.000007351785,0.00296074,0.0009912658,0.007358632,0.007402833],"study_design_scores_gemma":[0.1591865,0.0004513166,0.8341568,0.0003913639,0.0001721287,0.00005305677,0.0002760085,0.0004030369,0.003666626,0.0002190976,0.0008220847,0.0002019885],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953279,0.00009191551,0.000001056032,0.0001740742,0.00001782944,0.0004375717,0.0000143884,0.00009153478,0.003843741],"genre_scores_gemma":[0.9935119,0.00004711205,0.0001965594,0.00004067531,0.00002145245,0.00006464153,0.0001023638,0.00002418181,0.00599115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1538027,"threshold_uncertainty_score":0.3265369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01767307885723865,"score_gpt":0.2852902259037935,"score_spread":0.2676171470465548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}