{"id":"W4389235718","doi":"10.1016/j.nsa.2023.103928","title":"Chronic activation of the small-conductance, calcium-activated potassium channel precipitates age-dependent depressive-like behavior and cognitive deficits and reduces klotho concentration.","year":2023,"lang":"en","type":"article","venue":"Neuroscience Applied","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Fondation pour la Recherche sur la Biodiversite","keywords":"Internal medicine; Endocrinology; Prefrontal cortex; Cognitive decline; Psychology; Hippocampus; Behavioural despair test; Hippocampal formation; Chemistry; Neuroscience; Antidepressant; Cognition; Medicine; Dementia; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007707442,0.0004255289,0.0004388899,0.0002298961,0.0001041848,0.0001525251,0.0001591137,0.000301954,0.0007497286],"category_scores_gemma":[0.00008168141,0.0001496245,0.0002294492,0.0001213264,0.0002693952,0.0002025367,0.0001367106,0.0007693607,0.0001843646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002187892,"about_ca_system_score_gemma":0.0001523484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007414197,"about_ca_topic_score_gemma":0.002100457,"domain_scores_codex":[0.9999182,0.000007433243,0.000008092252,0.00001943305,0.00001825608,0.00002859935],"domain_scores_gemma":[0.9998736,0.000009332416,0.00005516804,0.000008618144,0.00001033132,0.00004282603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002593686,0.00008033293,0.0006061067,0.00002988235,0.000008952907,0.00007349974,0.00001134734,0.00001388926,0.9979936,0.00001678792,0.00003088734,0.0008754187],"study_design_scores_gemma":[0.0001399748,0.006206356,0.08541799,0.00001726151,0.00009093657,0.001151166,0.00009258777,0.0008014534,0.9045938,0.00009855926,0.001375971,0.00001393926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971097,0.00150876,0.0005922359,0.0000754825,0.0000200876,0.00001733169,0.0002744886,0.00005708536,0.0003447751],"genre_scores_gemma":[0.9959744,0.001292528,0.0008638955,0.00006883888,0.00001322883,0.00004528168,0.0004349855,0.00001076071,0.001296216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007497286,"threshold_uncertainty_score":0.002508104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05816806542336225,"score_gpt":0.3169145509553297,"score_spread":0.2587464855319675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}