{"id":"W4389239308","doi":"10.1002/advs.202304648","title":"Small Extracellular Vesicles Derived from Altered Peptide Ligand‐Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4<sup>+</sup> T cell‐Mediated Neuroprotective Immunity","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China; Natural Science Foundation of Heilongjiang Province; Postdoctoral Scientific Research Development Fund of Heilongjiang Province","keywords":"Neuroprotection; Peptide; Extracellular; Spinal cord; Spinal cord injury; Vesicle; Chemistry; Extracellular vesicles; Cell; Dendritic cell; Ligand (biochemistry); Immunity; Immune system; Cell biology; Biophysics; Immunology; Biology; Pharmacology; Biochemistry; Neuroscience; Receptor; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102096,0.0002777215,0.0002121795,0.0001443271,0.000104728,0.0002469424,0.000113673,0.0003411704,0.0007219448],"category_scores_gemma":[0.00007760364,0.00007974051,0.0001841403,0.00007816311,0.0001602097,0.0002224096,0.0001936228,0.0003399278,0.0002546413],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712207,"about_ca_system_score_gemma":0.0001817058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001714911,"about_ca_topic_score_gemma":0.0001932027,"domain_scores_codex":[0.9999329,0.00001182483,0.000008169493,0.00001008538,0.00001911385,0.0000178728],"domain_scores_gemma":[0.9999727,0.000003586018,0.000008077812,0.000002376544,0.000006050613,0.000007173914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001167842,0.0000344658,0.00008708891,0.00006417884,0.00000578937,0.00004196298,0.000005892952,0.0001531195,0.9972309,0.0001845227,0.00006270129,0.002012462],"study_design_scores_gemma":[0.0000463998,0.0005624953,0.0008346356,0.000009858684,0.00002775274,0.0001887477,0.00001705019,0.00145758,0.9932669,0.00009223339,0.003491796,0.000004566896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987508,0.003016872,0.007127137,0.0002026325,0.0001261749,0.00008457838,0.0001854175,0.00007599814,0.001673211],"genre_scores_gemma":[0.9936311,0.001447037,0.002712312,0.00006606837,0.00002202662,0.00004641845,0.0002362743,0.00001207973,0.001826729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007219448,"threshold_uncertainty_score":0.002415121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02646566300756126,"score_gpt":0.2982136590338677,"score_spread":0.2717479960263064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}