{"id":"W4389239308","doi":"10.1002/advs.202304648","title":"Small Extracellular Vesicles Derived from Altered Peptide Ligand‐Loaded Dendritic Cell Act as A Therapeutic Vaccine for Spinal Cord Injury Through Eliciting CD4<sup>+</sup> T cell‐Mediated Neuroprotective Immunity","year":2023,"lang":"en","type":"article","venue":"Advanced Science","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China; Natural Science Foundation of Heilongjiang Province; Postdoctoral Scientific Research Development Fund of Heilongjiang Province","keywords":"Neuroprotection; Peptide; Extracellular; Spinal cord; Spinal cord injury; Vesicle; Chemistry; Extracellular vesicles; Cell; Dendritic cell; Ligand (biochemistry); Immunity; Immune system; Cell biology; Biophysics; Immunology; Biology; Pharmacology; Biochemistry; Neuroscience; Receptor; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005219517,0.0004616918,0.0003540998,0.0001352185,0.000726312,0.0001298229,0.001170182,0.0001661112,0.00001457033],"category_scores_gemma":[0.0008466363,0.000482393,0.0002056589,0.0008858455,0.0004419464,0.0000777322,0.0004455133,0.0003610845,0.00007593331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007375729,"about_ca_system_score_gemma":0.0003802644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007682149,"about_ca_topic_score_gemma":0.000009274903,"domain_scores_codex":[0.9965835,0.0001896973,0.0005289676,0.001258319,0.000410725,0.001028848],"domain_scores_gemma":[0.9978647,0.0002029559,0.0003080581,0.001018182,0.0003178181,0.0002883482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001433188,0.0001523048,0.0001585901,0.00005658336,0.000023408,0.00003054399,0.0002616697,0.001096043,0.9902099,0.00001324301,0.000018389,0.006546155],"study_design_scores_gemma":[0.001700819,0.001619477,0.001823066,0.00007062513,0.00005882389,0.000008213896,0.0009407919,0.003466866,0.9873807,0.00168297,0.0006914082,0.0005561873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837235,0.002494558,0.01193165,0.000111983,0.000209371,0.001130086,0.0001182409,0.0001482461,0.0001323702],"genre_scores_gemma":[0.9908764,0.000273976,0.007489441,0.0004562472,0.0002067811,0.0002150933,0.0002091099,0.00009021803,0.000182702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00715294,"threshold_uncertainty_score":0.9997628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02646566300756126,"score_gpt":0.2982136590338677,"score_spread":0.2717479960263064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}