{"id":"W4389239758","doi":"10.1158/1535-7163.targ-23-b114","title":"Abstract B114: A Phase 1/1b study of KAZ954 alone and in combination with spartalizumab (PDR001) and taminadenant (NIR178) in patients with advanced gastrointestinal malignancies","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Pharmacokinetics; Tolerability; Cmax; Pharmacology; Gastroenterology; Internal medicine; Dosing; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109789,0.0001916554,0.0002172134,0.0001186186,0.00002972681,0.00001776931,0.0001031663,0.00006077912,0.000001798887],"category_scores_gemma":[0.00001139676,0.0001536645,0.00001757667,0.0003096951,0.0001463101,0.000007643533,0.0000849847,0.0001346218,2.588062e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002285786,"about_ca_system_score_gemma":0.00006187374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001505569,"about_ca_topic_score_gemma":0.0005003715,"domain_scores_codex":[0.9987587,0.00005125376,0.0002140644,0.0003884026,0.000278333,0.0003091838],"domain_scores_gemma":[0.9995191,0.000009475219,0.0000841525,0.0002115538,0.0001097525,0.00006603121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002414993,0.002118684,0.2083006,0.0001070706,0.00008344284,0.0001147774,0.0002802449,0.0001295695,0.7752914,0.000008316893,0.000003676976,0.01114716],"study_design_scores_gemma":[0.03042947,0.007364769,0.6468146,0.0003291803,0.00005162251,0.00001497556,0.0006336775,0.0002035326,0.3135449,0.00003467395,0.0001581891,0.0004203505],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985064,0.0005814256,0.0001478403,0.00008175614,0.000009052034,0.0006322514,0.00001805093,0.000007827174,0.00001544104],"genre_scores_gemma":[0.9994117,0.0001570738,0.0001597358,0.00006107962,0.000005012872,0.00009294896,0.00006835598,0.00003073759,0.00001337784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4617465,"threshold_uncertainty_score":0.6266258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472466673702168,"score_gpt":0.2881151742866683,"score_spread":0.2733905075496467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}