{"id":"W4389239758","doi":"10.1158/1535-7163.targ-23-b114","title":"Abstract B114: A Phase 1/1b study of KAZ954 alone and in combination with spartalizumab (PDR001) and taminadenant (NIR178) in patients with advanced gastrointestinal malignancies","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Pharmacokinetics; Tolerability; Cmax; Pharmacology; Gastroenterology; Internal medicine; Dosing; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00156004,0.001412808,0.001701954,0.0004707353,0.0003324698,0.0009333912,0.0007210881,0.0009520045,0.003686233],"category_scores_gemma":[0.0009162771,0.0006288586,0.001508077,0.0003883814,0.0007859063,0.0008425612,0.000354105,0.003214417,0.0009058011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009480006,"about_ca_system_score_gemma":0.001533157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009031335,"about_ca_topic_score_gemma":0.002631528,"domain_scores_codex":[0.999522,0.000263237,0.00002363608,0.00007802165,0.00004361672,0.00006952446],"domain_scores_gemma":[0.9995227,0.00008487765,0.00009635893,0.0000385491,0.00003091036,0.0002266424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6933102,0.09084331,0.01073174,0.001052775,0.00231752,0.00024076,0.0003674093,0.006101091,0.04996692,0.0003468035,0.004915979,0.1398054],"study_design_scores_gemma":[0.4020749,0.5718309,0.01566411,0.00003482117,0.0007324706,0.000252878,0.00007457325,0.002328954,0.003901069,0.0001997866,0.002870655,0.0000347038],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943827,0.001401447,0.0004577109,0.0003564649,0.0000662629,0.001200359,0.0008791181,0.00008097845,0.001175015],"genre_scores_gemma":[0.9917373,0.00123751,0.001699143,0.0005663885,0.0001047845,0.000911504,0.001570928,0.00003005122,0.002142474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003686233,"threshold_uncertainty_score":0.0123316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472466673702168,"score_gpt":0.2881151742866683,"score_spread":0.2733905075496467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}