{"id":"W4389239817","doi":"10.1158/1535-7163.targ-23-c053","title":"Abstract C053: BACE1 cleaves EGFR to drive lung adenocarcinoma brain metastasis","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Metastasis; Brain metastasis; Cancer research; Adenocarcinoma; Lung cancer; Cancer; In vivo; Medicine; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002791292,0.0005770381,0.0004068518,0.0005461141,0.00032836,0.0006066594,0.0004355951,0.0007178786,0.008433161],"category_scores_gemma":[0.0001752036,0.0002181647,0.0004142208,0.0002924008,0.0003166261,0.0002203701,0.0003113921,0.001241116,0.002734872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009004746,"about_ca_system_score_gemma":0.0006623981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002348422,"about_ca_topic_score_gemma":0.003384348,"domain_scores_codex":[0.9997272,0.00002495852,0.00001948396,0.00004500273,0.0001356792,0.00004773169],"domain_scores_gemma":[0.9998914,0.00001949899,0.00002088515,0.00001135739,0.00002510292,0.00003176889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001764999,0.0001077452,0.0002000614,0.00009775465,0.00001649934,0.0001870188,0.00001513292,0.0001777646,0.9859751,0.0007357193,0.004422092,0.007888612],"study_design_scores_gemma":[0.00007065741,0.0006033287,0.002168777,0.00001799802,0.00003295252,0.0008273943,0.00002170104,0.001225462,0.9612792,0.0002031973,0.03353615,0.00001306542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7873733,0.02326708,0.05157312,0.006367753,0.003308672,0.001656564,0.02280189,0.006605049,0.09704653],"genre_scores_gemma":[0.8903035,0.007162444,0.02027389,0.001166132,0.0001356802,0.000385056,0.009424863,0.0003286339,0.07081988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008433161,"threshold_uncertainty_score":0.02821171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0216947900026596,"score_gpt":0.3243851626453038,"score_spread":0.3026903726426442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}