{"id":"W4389239901","doi":"10.1158/2326-6074.tumimm23-b033","title":"Abstract B033: Multiplex analysis of the tumor immune microenvironment during treatment with atezolizumab/pelareorep/letrozole reveals novel immune-tumor interactions","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Atezolizumab; Tumor microenvironment; Immune system; Cancer research; Immunotherapy; Medicine; Cytotoxic T cell; Immunology; Biology; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003289063,0.0002756444,0.0004573877,0.0005049093,0.0004739424,0.00003637099,0.0005958957,0.00008614317,0.0002721396],"category_scores_gemma":[0.00006605288,0.000191567,0.0003691234,0.001425838,0.000741869,0.00001184181,0.0005438901,0.0003763393,0.00004771393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006207885,"about_ca_system_score_gemma":0.0003303626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004739879,"about_ca_topic_score_gemma":0.00170097,"domain_scores_codex":[0.9973999,0.0001814146,0.000445209,0.0006485107,0.0004254731,0.0008995062],"domain_scores_gemma":[0.9981901,0.00007504853,0.0001985199,0.001233704,0.0002023179,0.0001002924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001307423,0.000319623,0.03768696,0.00003242806,0.00523254,0.00003981045,0.0001402034,0.0005823341,0.953241,0.000006774331,0.00008418046,0.00132673],"study_design_scores_gemma":[0.001963251,0.0004091986,0.5307954,0.00006216718,0.0001576836,0.00002038162,0.0002956688,0.00003858246,0.4635235,0.000004928279,0.002590616,0.0001385922],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919835,0.006079746,0.000005337691,0.0004149401,0.0001119287,0.0007295487,0.0004520213,0.00001966756,0.0002033212],"genre_scores_gemma":[0.9924622,0.003073538,0.00003084889,0.00001438235,0.00006112125,0.0008928922,0.0002576792,0.00004594624,0.003161457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4931085,"threshold_uncertainty_score":0.7811876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03899828271051024,"score_gpt":0.3539340456493098,"score_spread":0.3149357629387995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}