{"id":"W4389239921","doi":"10.1158/2326-6074.tumimm23-a015","title":"Abstract A015: Rapid mitochondrial reactive oxygen species production precedes NF-κB activation and pro-inflammatory responses in macrophages","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Reactive oxygen species; Proinflammatory cytokine; Chemistry; Cell biology; Mitochondrial ROS; Lipopolysaccharide; Inflammation; NF-κB; Context (archaeology); Pharmacology; Signal transduction; Biochemistry; Immunology; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001609569,0.0002215433,0.0003083732,0.0009967707,0.0005770081,0.00004969693,0.0002613713,0.0005014318,0.0004170967],"category_scores_gemma":[0.001001263,0.0002074314,0.00005366317,0.000791213,0.001053579,0.0003566115,0.0001978625,0.0009241435,0.0003865002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667881,"about_ca_system_score_gemma":0.0003721957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000190327,"about_ca_topic_score_gemma":0.0001550689,"domain_scores_codex":[0.9971229,0.0009469789,0.0004318896,0.0006229932,0.0001296928,0.0007455302],"domain_scores_gemma":[0.9984195,0.000665404,0.0001497606,0.0003823957,0.0003569335,0.00002602272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003822849,0.00004773067,0.00507185,0.00006923559,0.0001911304,0.00001734497,0.002430049,0.000004918651,0.9684386,0.0002986876,0.006209476,0.01339816],"study_design_scores_gemma":[0.0009672047,0.0001304131,0.3721599,0.0001106783,0.000005547783,0.00001790028,0.001754176,0.000001934324,0.6011088,0.0003175632,0.02326122,0.0001645862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899026,0.003512908,0.000002081368,0.002769668,0.001385992,0.001049488,0.00004929662,0.000145557,0.001182436],"genre_scores_gemma":[0.9848869,0.00320955,0.00001895121,0.00001657321,0.000246422,0.0007049155,0.0002299151,0.00003249328,0.01065426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3673297,"threshold_uncertainty_score":0.8458805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0801465144568929,"score_gpt":0.3446348295567334,"score_spread":0.2644883150998404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}