{"id":"W4389239940","doi":"10.1158/1535-7163.targ-23-a109","title":"Abstract A109: Targeting pyrimidine biosynthesis as a metabolic vulnerability in brain metastasis","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Pyrimidine metabolism; Dihydroorotate dehydrogenase; Metastasis; Cancer research; Biology; Cancer; Biochemistry; Pyrimidine; Purine; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008422824,0.0003474178,0.0003532417,0.0001905498,0.00009936434,0.00005656802,0.0004814435,0.00024633,0.0001471656],"category_scores_gemma":[0.0002591684,0.0003296346,0.0002805926,0.0008535474,0.0001677146,0.000007180479,0.0002715595,0.0003418401,0.00006881909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004502908,"about_ca_system_score_gemma":0.0001934287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000346254,"about_ca_topic_score_gemma":0.0000746458,"domain_scores_codex":[0.9973533,0.0002263365,0.0004116365,0.0007788001,0.0004458943,0.00078409],"domain_scores_gemma":[0.9989263,0.00005169196,0.00009075648,0.0006307031,0.0001244843,0.0001760112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001084651,0.0001096672,0.0009752608,0.00005032743,0.0002503441,0.00006674933,0.00005526769,0.0001766124,0.9758343,0.000150022,0.0005124518,0.0217105],"study_design_scores_gemma":[0.0005585624,0.00006210383,0.002099203,0.00002182306,0.00004478426,0.000004667707,0.00007283222,0.0001281444,0.9056367,0.000543463,0.0904587,0.0003689631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851944,0.009282744,0.0003211988,0.003970687,0.0001107751,0.0003928349,0.00006290407,0.00006741168,0.0005970452],"genre_scores_gemma":[0.9937997,0.002339045,0.0003294198,0.002761977,0.0001174006,0.0001924866,0.0001765208,0.0000880826,0.0001953969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08994625,"threshold_uncertainty_score":0.9999156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03632789048844697,"score_gpt":0.3446842506897804,"score_spread":0.3083563602013334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}