{"id":"W4389239946","doi":"10.1158/2326-6074.tumimm23-a024","title":"Abstract A024: Systemic administration of CD3-redirected lentiviral vector efficiently targets CD19-CAR delivery to human T cells in vivo","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD19; IL-2 receptor; Tropism; CD3; In vivo; Ex vivo; T cell; LDL receptor; Viral vector; Antibody; Biology; Cell biology; Molecular biology; Immunology; Antigen; Recombinant DNA; Immune system; CD8; Virus; Lipoprotein","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001751966,0.0004168409,0.0002723773,0.0002645416,0.0001727581,0.0003660211,0.0002389913,0.0004888412,0.003284847],"category_scores_gemma":[0.00007906714,0.0001374382,0.0002663181,0.0001471681,0.0002216929,0.0001619307,0.0001293611,0.0009905207,0.001159118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003301767,"about_ca_system_score_gemma":0.0003755195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001114792,"about_ca_topic_score_gemma":0.0009581001,"domain_scores_codex":[0.9998265,0.00002170582,0.00001417759,0.00004186021,0.00004133356,0.00005442367],"domain_scores_gemma":[0.9999506,0.000007184019,0.00001112072,0.00000839326,0.000008025649,0.00001467158],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002326671,0.0001369254,0.00007212889,0.00003680107,0.000006766115,0.00006315914,0.00001524308,0.00006254416,0.9958983,0.000150452,0.0003612663,0.002963735],"study_design_scores_gemma":[0.00008411707,0.0008069623,0.0008300022,0.000005154869,0.00001728973,0.0002275204,0.000007370276,0.0009249843,0.9926692,0.0000396089,0.004383515,0.000004266573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698274,0.002157013,0.01572337,0.0003182781,0.0002136337,0.0004333811,0.001809626,0.0009949924,0.00852241],"genre_scores_gemma":[0.9771481,0.0007039162,0.009472165,0.0001613449,0.00005221056,0.0002240121,0.00142608,0.0001252655,0.01068691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003284847,"threshold_uncertainty_score":0.01098889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04491017351373862,"score_gpt":0.3734585956384693,"score_spread":0.3285484221247307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}