{"id":"W4389239948","doi":"10.1158/1535-7163.targ-23-a161","title":"Abstract A161: A differentiation based therapeutic approach for KMT2A rearranged leukemia in infants and children","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Leukemia; Cancer research; Biology; Cellular differentiation; Childhood leukemia; Immunology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217174,0.0002989008,0.0002719896,0.0003017005,0.0001557729,0.0002131683,0.0002252748,0.0002374711,0.001718781],"category_scores_gemma":[0.00007650952,0.00008183446,0.000208509,0.0002195681,0.0001458438,0.0001185941,0.0002277801,0.000522185,0.0004852063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012909,"about_ca_system_score_gemma":0.0003890282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004134335,"about_ca_topic_score_gemma":0.0007352827,"domain_scores_codex":[0.9999446,0.00001037159,0.000005145866,0.00001183572,0.00001515949,0.00001294512],"domain_scores_gemma":[0.999965,0.000003492074,0.00001054248,0.000002540497,0.000005048297,0.00001349943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003110549,0.0008687444,0.009043418,0.0005958825,0.00007178833,0.002195264,0.0001275421,0.0008344968,0.8326164,0.0008069224,0.002990697,0.1467382],"study_design_scores_gemma":[0.000936967,0.01751779,0.09275439,0.0002323187,0.0002514968,0.02414586,0.0002831991,0.002541434,0.7607866,0.0006333962,0.09986774,0.00004890085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.971176,0.01749724,0.004152069,0.0006293804,0.000109566,0.0001919081,0.0009335258,0.0003010093,0.005009343],"genre_scores_gemma":[0.973673,0.01228681,0.007311766,0.0002671804,0.000050428,0.0001803609,0.001192319,0.00003502953,0.005003161],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718781,"threshold_uncertainty_score":0.005749941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02331749052183711,"score_gpt":0.2792136968362858,"score_spread":0.2558962063144487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}