{"id":"W4389240146","doi":"10.1158/1535-7163.targ-23-a034","title":"Abstract A034: Synthesis and biological activities of a novel series of “combi-molecules” designed to delay metabolic dealkylation prior to crossing the blood brain barrier in the context of optimizing their potency against glioblastoma multiforme","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Gefitinib; Temozolomide; Pharmacology; Context (archaeology); Cancer research; In vivo; Tyrosine kinase; Epidermal growth factor receptor; U87; Potency; Chemistry; Medicine; Cancer; Biology; Internal medicine; In vitro; Signal transduction; Glioma; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007655245,0.0003240161,0.000157027,0.0001945549,0.00007931543,0.0001421373,0.0003224614,0.0002420419,0.001905714],"category_scores_gemma":[0.00008431713,0.00007879624,0.0001752068,0.0001257973,0.00009093878,0.00016226,0.00007724483,0.0002292476,0.0003952582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001732548,"about_ca_system_score_gemma":0.0001457538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004912697,"about_ca_topic_score_gemma":0.0006632449,"domain_scores_codex":[0.9999665,0.000004758812,0.000003280555,0.000009222621,0.000007471805,0.000008623088],"domain_scores_gemma":[0.9999654,0.000003680384,0.000009616529,0.000002672248,0.000006262228,0.0000122938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004860524,0.0002957939,0.0001448532,0.0001615442,0.00001946031,0.0000728489,0.00001846423,0.0004899975,0.9836305,0.0002715326,0.0003793703,0.0140296],"study_design_scores_gemma":[0.0004294794,0.008323103,0.003671241,0.00001855266,0.00006896515,0.0003452618,0.00002059764,0.003404282,0.9729024,0.00007905091,0.01070736,0.00002967045],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889138,0.0030162,0.003100252,0.0001073763,0.00006420663,0.0001330525,0.0006002076,0.0001220154,0.003942727],"genre_scores_gemma":[0.9905377,0.001440982,0.004197521,0.0001064456,0.00001991792,0.00008440837,0.0007251763,0.00001765843,0.002870168],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001905714,"threshold_uncertainty_score":0.006375253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0347430759803625,"score_gpt":0.2932496063632243,"score_spread":0.2585065303828618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}