{"id":"W4389240186","doi":"10.1158/1535-7163.targ-23-a045","title":"Abstract A045: EZH2 inhibition re-sensitizes drug resistant triple-negative breast cancer PDX models to Eribulin","year":2023,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"","keywords":"Eribulin; Medicine; Breast cancer; Oncology; Internal medicine; Metastatic breast cancer; Cancer; Drug resistance; Triple-negative breast cancer; Cancer research; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002185259,0.0003217119,0.0003807843,0.0003220077,0.0002554856,0.0004608554,0.0003003325,0.0004742463,0.004191738],"category_scores_gemma":[0.0001228906,0.0001446769,0.0003796784,0.0002006396,0.0003442778,0.0002186136,0.0002035354,0.001371852,0.0009487772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005011492,"about_ca_system_score_gemma":0.0003057923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001188449,"about_ca_topic_score_gemma":0.001453449,"domain_scores_codex":[0.9997503,0.00002218333,0.00002303543,0.00006663991,0.00008932827,0.00004841322],"domain_scores_gemma":[0.9998689,0.00001652568,0.00002870524,0.0000208184,0.00001897127,0.00004612039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005122415,0.0002048023,0.0004286136,0.00008167049,0.00001857966,0.00008943448,0.00004603807,0.0003596584,0.993108,0.0004571286,0.001242908,0.003450877],"study_design_scores_gemma":[0.00009829104,0.001585647,0.005101309,0.00001841175,0.00004498796,0.000345174,0.0001144387,0.003426921,0.9743524,0.0001698153,0.01472915,0.00001357263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735642,0.001186506,0.008020315,0.0006001699,0.0002547025,0.0002061867,0.009445637,0.0005248407,0.006197421],"genre_scores_gemma":[0.9681845,0.0008265929,0.004546335,0.0003603046,0.00002338176,0.0003282134,0.007190109,0.0001331045,0.01840738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004191738,"threshold_uncertainty_score":0.01402271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03304878802845244,"score_gpt":0.2966544918079616,"score_spread":0.2636057037795091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}