{"id":"W4389240203","doi":"10.1158/2326-6074.tumimm23-a005","title":"Abstract A005: Synergistically Engaging a b-Selective IL-2 Agonist with PD1/PDL-1 Blockade in a Bifunctional Superkine, MDNA223","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD8; In vivo; Cancer research; Pharmacology; Flow cytometry; Cancer immunotherapy; Peripheral blood mononuclear cell; Tumor-infiltrating lymphocytes; Chemistry; Immunotherapy; Agonist; Blockade; T cell; In vitro; Medicine; Receptor; Immunology; Immune system; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001039587,0.0002758995,0.0001679624,0.000129794,0.00007251726,0.0002292561,0.000177952,0.0002334165,0.001337773],"category_scores_gemma":[0.00005755612,0.00005887023,0.0001684964,0.00006977948,0.0001302028,0.0001127831,0.0001537722,0.0003117081,0.0003286735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931702,"about_ca_system_score_gemma":0.0001585644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002203911,"about_ca_topic_score_gemma":0.0002702106,"domain_scores_codex":[0.9999201,0.00001424059,0.000007605063,0.00001655293,0.00002366454,0.00001772081],"domain_scores_gemma":[0.9999636,0.000006531129,0.000009364694,0.000003243161,0.000002893233,0.00001431223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003163689,0.00008785321,0.0001348104,0.00004734415,0.000006758522,0.0000379149,0.000008497069,0.0002599187,0.9959273,0.0001002728,0.00011903,0.002953798],"study_design_scores_gemma":[0.0000706256,0.001382007,0.0007620338,0.000005606124,0.00001834995,0.0002020776,0.000008568315,0.001537218,0.9934272,0.00002849915,0.002552497,0.000005384507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929363,0.001055664,0.003345907,0.00009278876,0.00004248787,0.0000811393,0.0002857065,0.00009079486,0.002069136],"genre_scores_gemma":[0.9944478,0.000250177,0.003479534,0.00004834036,0.000009905324,0.00005100056,0.0002641632,0.000007265851,0.00144162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337773,"threshold_uncertainty_score":0.004475296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03985302018752771,"score_gpt":0.3439356423174856,"score_spread":0.3040826221299579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}