{"id":"W4389240203","doi":"10.1158/2326-6074.tumimm23-a005","title":"Abstract A005: Synergistically Engaging a b-Selective IL-2 Agonist with PD1/PDL-1 Blockade in a Bifunctional Superkine, MDNA223","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"CD8; In vivo; Cancer research; Pharmacology; Flow cytometry; Cancer immunotherapy; Peripheral blood mononuclear cell; Tumor-infiltrating lymphocytes; Chemistry; Immunotherapy; Agonist; Blockade; T cell; In vitro; Medicine; Receptor; Immunology; Immune system; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009439006,0.0002460747,0.0003130226,0.0004477109,0.0003351031,0.00005370676,0.0004164037,0.0003145723,0.0001915289],"category_scores_gemma":[0.0003668651,0.0002268649,0.00008662362,0.001150455,0.0007993809,0.00001123023,0.0002521657,0.001051078,0.00008531118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001593053,"about_ca_system_score_gemma":0.001195913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001042467,"about_ca_topic_score_gemma":0.001714905,"domain_scores_codex":[0.9971901,0.0002467351,0.0002940756,0.0007784332,0.0004002296,0.001090459],"domain_scores_gemma":[0.9987583,0.0001543755,0.00005194782,0.0004738442,0.0004384272,0.0001230824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001622895,0.0001357524,0.002708013,0.0000454613,0.000337029,0.00004798047,0.0002336998,0.0003190298,0.9672467,0.0003041903,0.0121341,0.01486521],"study_design_scores_gemma":[0.003883121,0.0008269583,0.1986659,0.0001301237,0.00003930965,0.00009411224,0.001020859,0.0001186302,0.1229743,0.0002945192,0.6712806,0.0006715221],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837956,0.008648684,0.00005606232,0.001273688,0.0007957786,0.0004418962,0.0001244322,0.00005969802,0.004804158],"genre_scores_gemma":[0.9863774,0.005450009,0.00007164035,0.000102304,0.001486546,0.0006857824,0.0001930335,0.00006335055,0.005569948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8442723,"threshold_uncertainty_score":0.9251282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03985302018752771,"score_gpt":0.3439356423174856,"score_spread":0.3040826221299579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}