{"id":"W4389240413","doi":"10.1158/2326-6074.tumimm23-b014","title":"Abstract B014: Spatial genomics identifies cancer cell cytokines regulating ovarian cancer immunity","year":2023,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tumor microenvironment; Ovarian cancer; Immunotherapy; Cancer research; Cancer; Immune system; Biology; Immune checkpoint; Cancer immunotherapy; T cell; CRISPR; Immunology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008623462,0.0002981965,0.0003389129,0.0001807164,0.0006955758,0.0001081395,0.0007980878,0.0004847737,0.0006816018],"category_scores_gemma":[0.00009690639,0.0003048431,0.0001561779,0.0004442944,0.0005900589,0.00002015155,0.0004593124,0.0007147966,0.0000626558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836625,"about_ca_system_score_gemma":0.0008375125,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04674422,"about_ca_topic_score_gemma":0.01684454,"domain_scores_codex":[0.9972107,0.0002588974,0.0004414984,0.0006974999,0.0003322057,0.001059225],"domain_scores_gemma":[0.9984098,0.00008934527,0.0001323708,0.000744932,0.0005117144,0.0001118235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000428961,0.00006491624,0.009501618,0.0001002422,0.0002283523,0.000009723753,0.0004302933,0.000536254,0.9708858,0.00001315783,0.003082613,0.01471813],"study_design_scores_gemma":[0.001295074,0.0001379482,0.1052328,0.00008503003,0.00003064256,0.00000407083,0.0006509674,0.0002953284,0.8647531,0.000137397,0.0269411,0.0004365286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800974,0.01564225,0.00005340081,0.0007486179,0.001690164,0.0003812856,0.0002158088,0.0000721566,0.001098962],"genre_scores_gemma":[0.9671905,0.02649738,0.00003938076,0.00009416819,0.001083255,0.0004529379,0.0002319092,0.0000885731,0.004321858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1061327,"threshold_uncertainty_score":0.9999404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06805472660407133,"score_gpt":0.3542901432539164,"score_spread":0.2862354166498451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}